Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Cardiovascular >> Lipids / Lipoproteins >> Adipose Related >> Acrp
Overview
Product name
Anti-Adiponectin Receptor 1 antibody - Carboxyterminal end
See all Adiponectin Receptor 1 products (9) ...
Description
Goat polyclonal to Adiponectin Receptor 1 - Carboxyterminal end
Tested applications
IHC-P, WB, ICCmore details
Cross reactivity
Reacts with
Human
Immunogen
25 amino acid synthetic peptide VAAAFVHFYGVSNLQEFRYGLEGGC corresponding to aa 345-369 of the C-terminal domain of Human Adiponectin Receptor 1. Peptide availabe as ab88858 - Adiponectin Receptor 1 peptide (345-369) Note: Peptide sequence is < 50 % identical to other receptors in this region.
VAAAFVHFYG VSNLQEFRYG LEGGC
Positive control
Human liver; human muscle.
General notes
AdipoR1 is highly conserved in species ranging from microorganisms to humans, and ab53398 recognizes AdipoR1 in multiple species.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 1mg/ml BSA, 140mM Sodium chloride, 10mM Potassium phosphate, pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Growth Factors/Hormones >> Hormones
Cardiovascular >> Lipids / Lipoproteins >> Adipose Related >> Acrp
Applications
Show applications key
Our Abpromise guarantee covers the use of ab53398 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
ICC
Application notes
ICC: 1/400.
IHC-P: 1/250.
WB: 1/1000. Predicted molecular weight: 42 kDa. Can be blocked with Adiponectin Receptor 1 peptide (345-369) (ab88858).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.
Tissue specificity
Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
Sequence similarities
Belongs to the ADIPOR family.
Domain
The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
Cellular localization
Membrane. Localized to the cell membrane and intracellular organelles.
Target information above from: UniProt accessionQ96A54
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ACDCR1 antibody
- ADIPO R1 antibody
- Adiponectin receptor protein 1 antibody
see all
Database links
- Entrez Gene: 51094 Human
- Omim: 607945 Human
- SwissProt: Q96A54 Human
- Unigene: 5298 Human
Anti-Adiponectin Receptor 1 antibody - Carboxyterminal end images:
Immunohistochemistry (Paraffin-embedded sections) - Adiponectin Receptor 1 antibody (ab53398)
IH paraffin section of human liver using ab53398 at a dilution of 1/250.
Immunohistochemistry (Paraffin-embedded sections) - Adiponectin Receptor 1 antibody (ab53398)
IH paraffin section of human muscle using ab53398 at a dilution of 1/250.
References for Anti-Adiponectin Receptor 1 antibody - Carboxyterminal end (ab53398)
ab53398 has not yet been referenced specifically in any publications.
Publishing research using ab53398? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"