Anti-Adiponectin Receptor 2 antibody (ab40446)

Overview

• Product nameAnti-Adiponectin Receptor 2 antibodySee all Adiponectin Receptor 2 primary antibodies ...
• Description
  Rabbit polyclonal to Adiponectin Receptor 2
• SpecificityRecognizes mouse AdipoR2.
• Tested applicationsIP more details
• Species reactivity
  Reacts with: Mouse
  Predicted to work with: Rat, Chicken, Human
• Immunogen

  Synthetic peptide: NEPAKHRLGC TRTPEPDIRL RKGHQLDDTR GSNND, corresponding to amino acids 2-36 of Mouse Adiponectin Receptor 2

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Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: Whole serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Diabetes

  • Metabolism
  • Types of disease
  • Heart disease

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Fatty acid oxidation

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Fatty acids

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipoprotein metabolism

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Cardiovascular
  • Atherosclerosis
  • Lipoprotein metabolism

  • Cardiovascular
  • Lipids / Lipoproteins
  • Fatty Acids
  • Metabolism

  • Cardiovascular
  • Atherosclerosis
  • Diabetes associated

Applications

Target

• FunctionReceptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.
• Tissue specificityHighly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.
• Sequence similaritiesBelongs to the ADIPOR family.
• DomainThe N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
• Cellular localizationMembrane. Localized to the cell membrane and intracellular organelles.

Target information above from: UniProt accession Q86V24 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 418155 Chicken
  • Entrez Gene: 79602 Human
  • Entrez Gene: 79602 Human
  • Entrez Gene: 68465 Mouse
  • Entrez Gene: 312670 Rat
  • Omim: 607946 Human
  • SwissProt: Q4PKP1 Chicken
  • SwissProt: Q86V24 Human

  • SwissProt: Q86V24 Human
  • SwissProt: Q53YY3 Mouse
  • SwissProt: Q8BQS5 Mouse
  • SwissProt: Q3YAF7 Rat
  • Unigene: 371642 Human
  • Unigene: 708545 Human
  • Unigene: 291826 Mouse

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• Alternative names
  PAQR2 antibodyAdiponectin receptor protein 2 antibodyAdipor2 antibody

  ADR2_HUMAN antibodyProgestin and adipoQ receptor family member II antibody

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