Anti-Aggrecan ARGxx antibody [BC-3] (ab3773)

ab3773 has been referenced in 13 publications.

1. Funck-Brentano T et al. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. PLoS One 7:e33543 (2012). WB; Human. PubMed: 22432033
2. Wang J et al. TNF-a and IL-1ß Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc. J Biol Chem 286:39738-49 (2011). WB; Human. PubMed: 21949132
3. Torzilli PA et al. Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage. Osteoarthritis Cartilage 18:97-105 (2010). PubMed: 19747586
4. Sondergaard BC et al. MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis Cartilage 18:279-88 (2010). Sandwich ELISA; Cow. PubMed: 19932675
5. Madsen SH et al. Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo. Biomarkers 15:266-76 (2010). PubMed: 20039789
6. Echtermeyer F et al. Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med 15:1072-6 (2009). IHC-P. PubMed: 19684582
7. Rousseau JC et al. Patients with rheumatoid arthritis have an altered circulatory aggrecan profile. BMC Musculoskelet Disord 9:74 (2008). WB; Human. PubMed: 18507823
8. Karsdal MA et al. Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res Ther 10:R63 (2008). ELISA; Cow. PubMed: 18513402
9. Karsdal MA et al. Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. Arthritis Rheum 56:1549-58 (2007). PubMed: 17469134
10. Shao X & Hunter CJ Developing an alginate/chitosan hybrid fiber scaffold for annulus fibrosus cells. J Biomed Mater Res A 82:701-10 (2007). PubMed: 17326226
11. Llamazares M et al. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci 120:3544-52 (2007). WB; Dog. PubMed: 17895370
12. Molecular Approaches to Osteoarthritis Research. Abstracts of the Kennedy Institute of Rheumatology Symposium, London, United Kingdom, April 18-20, 2004. Scand J Rheumatol Suppl :1-41 (2005). PubMed: 15864865
13. Innes JF et al. Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis. Am J Vet Res 66:1679-85 (2005). PubMed: 16273897