Potent isozyme selective Akt1/2 kinase inhibitor. (IC50 values are 58, 210 nM and 2.12 mM for Akt1, Akt2, and Akt3, respectively). No inhibition against pleckstrin homology (PH) domain-lacking Akts, PKA, PKC and SGK.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Akt Inhibitor (Akti-1/2) (ab142088)
This product has been referenced in:
Ajmani S et al. A comprehensive structure-activity analysis of protein kinase B-alpha (Akt1) inhibitors. J Mol Graph Model28:683-94 (2010).
Read more (PubMed: 20153226) »
Gilot D et al. Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIa activity and aryl hydrocarbon receptor pathway. Chem Biol Interact188:546-52 (2010).
Read more (PubMed: 20832391) »
DeFeo-Jones D et al. Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members. Mol Cancer Ther4:271-9 (2005).
Read more (PubMed: 15713898) »
Barnett SF et al. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem J385:399-408 (2005).
Read more (PubMed: 15456405) »
Zhang X & Vik TA Growth factor stimulation of hematopoietic cells leads to membrane translocation of AKT1 protein kinase. Leuk Res21:849-56 (1997).
Read more (PubMed: 9393600) »