Overview

  • Product name
    Anti-Aldolase antibody - N-terminal
    See all Aldolase primary antibodies
  • Description
    Rabbit polyclonal to Aldolase - N-terminal
  • Tested applications
    Suitable for: IHC-P, ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide from the N-terminal region of human Aldolase conjugated to KLH

  • Positive control
    • CEM cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab71433 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50.
ELISA 1/1000.
WB 1/50 - 1/100. Detects a band of approximately 36 kDa (predicted molecular weight: 39 kDa).

Target

  • Function
    Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.
  • Pathway
    Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
  • Involvement in disease
    Defects in ALDOA are the cause of glycogen storage disease type 12 (GSD12) [MIM:611881]; also known as red cell aldolase deficiency. A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
  • Sequence similarities
    Belongs to the class I fructose-bisphosphate aldolase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALDA antibody
    • Aldo1 antibody
    • ALDOA antibody
    • ALDOA_HUMAN antibody
    • Aldolase 1 antibody
    • Aldolase A antibody
    • Aldolase A fructose bisphosphatase antibody
    • Aldolase A fructose bisphosphate antibody
    • Aldolase, fructose-bisphosphate A antibody
    • Epididymis secretory sperm binding protein Li 87p antibody
    • FRUCTOALDOLASE A antibody
    • Fructose 1 6 bisphosphate triosephosphate lyase antibody
    • Fructose bisphosphate aldolase A antibody
    • Fructose bisphosphate aldolase antibody
    • FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE A antibody
    • Fructose-bisphosphate aldolase A antibody
    • Fructose-bisphosphate aldolase A Muscle-type antibody
    • GSD12 antibody
    • HEL S 87p antibody
    • Lung cancer antigen NY LU 1 antibody
    • Lung cancer antigen NY-LU-1 antibody
    • MGC10942 antibody
    • MGC17716 antibody
    • MGC17767 antibody
    • Muscle type aldolase antibody
    • Muscle-type aldolase antibody
    • RNALDOG5 antibody
    see all

Images

  • Anti-Aldolase antibody - N-terminal (ab71433) at 1/60 dilution + CEM cell line lysate at 35 µg

    Predicted band size : 39 kDa
    Observed band size : 36 kDa (why is the actual band size different from the predicted?)
  • ab71433 at 1/50 dilution staining Aldolase - N - terminal in human lung carcinoma tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.

References

This product has been referenced in:
  • Zhang F  et al. Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors. BioData Min 10:6 (2017). Read more (PubMed: 28191039) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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