Alpha 1 microglobulin protein (ab96148)
Constituents: 0.02M Ammonium bicarbonate
(May contain traces of buffer salts)
Our Abpromise guarantee covers the use of ab96148 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|RID||RID: Use at an assay dependent dilution.|
|SDS-PAGE||SDS-PAGE: Use at an assay dependent dilution.|
- A1MAlpha 1 microglobulin/bikunin precursorAlpha 1 microglycoprotein
- Alpha-1 microglycoproteinAlpha-1-microglobulinAMBPAMBP_HUMANBikuninComplex-forming glycoprotein heterogeneous in chargeEDC1Growth inhibiting protein 19HCPHI-30HI30IATILInter-alpha-trypsin inhibitor light chainITIITI-LCITILMicroglobulin (alpha 1)Protein AMBPProtein HCTrypstatinUristatinUronic-acid-rich proteinUTI
Trypstatin is a trypsin inhibitor.
Contains 2 BPTI/Kunitz inhibitor domains.
modificationsThe precursor is proteolytically processed into separately functioning proteins.
3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.
Addition of glycosaminoglycan chondroitin sulfate, allows cross-linking between the different components.
References for Alpha 1 microglobulin protein (ab96148)
ab96148 has not yet been referenced specifically in any publications.