Overview

  • Product name
    Anti-Aminoacylase 1 antibody
    See all Aminoacylase 1 primary antibodies
  • Description
    Rabbit polyclonal to Aminoacylase 1
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 89 and 336 of Human Aminoacylase 1 (NP_000657).

  • Positive control
    • 293T, A431, HeLa, HepG2, MOLT4, H1299 and Raji cell lysates ICC/IF: A431 cell

Properties

Applications

Our Abpromise guarantee covers the use of ab96098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 46 kDa.
ICC/IF 1/100 - 1/200.

Target

  • Function
    Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
  • Tissue specificity
    Expression is highest in kidney, strong in brain and weaker in placenta and spleen.
  • Involvement in disease
    Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D) [MIM:609924]. ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.
  • Sequence similarities
    Belongs to the peptidase M20A family.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACY 1 antibody
    • ACY-1 antibody
    • Acy1 antibody
    • ACY1_HUMAN antibody
    • ACY1D antibody
    • ACYLASE antibody
    • Acylase I antibody
    • Aminoacylase-1 antibody
    • EC 3.5.1.14 antibody
    • epididymis secretory protein Li 5 antibody
    • HEL-S-5 antibody
    • N acyl L amino acid amidohydrolase antibody
    • N-acyl-L-amino-acid amidohydrolase antibody
    • OTTHUMP00000212459 antibody
    • OTTHUMP00000212462 antibody
    • OTTHUMP00000212463 antibody
    • OTTHUMP00000212464 antibody
    • OTTHUMP00000212465 antibody
    see all

Images

  • Anti-Aminoacylase 1 antibody (ab96098) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 46 kDa
  • Immunofluorescence analysis of Aminoacylase 1 in paraformaldehyde fixed A431, using ab96098 at a 1/200 dilution. Lower image merged with DNA probe.

References

ab96098 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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