Anti-Amyloid Precursor Protein Frameshift Mutant antibody (ab2085)

Overview

  • Product nameAnti-Amyloid Precursor Protein Frameshift Mutant antibodySee all Amyloid Precursor Protein Frameshift Mutant primary antibodies ...
  • Description
    Goat polyclonal to Amyloid Precursor Protein Frameshift Mutant
  • Tested applicationsELISA, WB, IHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to amino acids 339-348 of the C-terminal Human Amyloid Precursor Protein Frameshift Mutant .

Properties

Applications

Our Abpromise guarantee covers the use of ab2085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA
WB
IHC-P
  • Application notesELISA: 1/5000.
    IHC-P: 1/300.
    WB: 1/3000. Detects a band of approximately 45 kDa.

    IHC labels dystrophic neurites in senile plaques and shows immunoreactivity with neurons containing the APPFM protein.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceAmyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimers disease patients and Downs Syndrome patients.
    • Cellular localizationCell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus
    • Database links
    • Alternative names
      • AAA antibody
      • ABETA antibody
      • ABPP antibody
      • AD1 antibody
      • Alzheimer's disease 1 antibody
      • Amyloid beta A4 precurser protein antibody
      • Amyloid beta-peptide antibody
      • APP antibody
      • APPFM antibody
      • APPI antibody
      • Cerebral vascular amyloid peptide antibody
      • CVAP antibody
      • PN2 antibody
      see all

    References for Anti-Amyloid Precursor Protein Frameshift Mutant antibody (ab2085)

    ab2085 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"