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Synthetic peptide conjugated to KLH derived from within residues 750 to the C-terminus of Human Amyloid Precursor Protein, phosphorylated at Y757.
(Peptide available as ab20648.)
Phosphorylation of APP at Tyr757 and 762 is important for MAPK8IP1, APBA1, shcA/shcC and DAB1 binding. Binding interactions regulated by phosphorylation determine the localisation and the function of APP. Therefore Amyloid Precursor Protein (phospho Y757) antibody will be a useful tool in tracing the processing, distribution and interaction of APP.
Our Abpromise guarantee covers the use of ab19850 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55, 87, 110, 170 kDa (predicted molecular weight: 55, 87, 110 kDa).Can be blocked with Human Amyloid Precursor Protein (phospho Y757) peptide (ab20648).|
|IHC||Use at an assay dependent concentration. ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.|
Florian Plattner, Wolfson Inst Biomed Research, United Kingdom
ab19850 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"