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Immunohistochemistry (Paraffin-embedded sections) - Androgen Receptor antibody (ab47569)
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Product Name
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Androgen Receptor antibody
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See all Androgen Receptor antibodies (22)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Androgen Receptor
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Immunogen
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Synthetic non-phosphopeptide derived from human Androgen Receptor around the phosphorylation site of serine 213 (E-A-SP-G-A).
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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ELISA, IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: 1/64,000.
IHC-P: 1/50 - 1/100.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Human prostate carcinoma tissue.
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Cellular localization
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Nuclear
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Research areas
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Developmental Biology >> Reproduction >> Hormones
Cancer >> Signal transduction >> Nuclear signaling >> Nuclear hormone receptors >> Other
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Testosterone
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Testosterone
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Relevance
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Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain.
The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.
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Androgen Receptor antibody (ab47569) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4 Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at -20°C. Stable for 12 months at -20°C
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Androgen Receptor antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for Androgen Receptor antibody images, references, products related to ab47569 and other tools.
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Androgen Receptor antibody images:
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 Immunohistochemistry (Paraffin-embedded sections) - Androgen Receptor antibody (ab47569)
This image shows human Prostate Carcinoma tissue ( left hand image - without immunogenic peptide, right hand image with immunogenic peptide) stained with ab47569 at 1/50 dilution.
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Search PubMed (MEDLINE) for references to Androgen Receptor
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Androgen Receptor antibody - more information
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Customer reviews (feedback) regarding Androgen Receptor antibody |
Customer FAQs regarding Androgen Receptor antibody |
Protocols for Androgen Receptor antibody |
Price and availability of products related to Androgen Receptor antibody |
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Androgen Receptor antibody - related products:
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Androgen Receptor antibody - other tools:
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Contact Abcam with a Technical Enquiry about Androgen Receptor antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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