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Products:Cardiovascular >> Angiogenesis >> Growth Factors >> Angiopoietin
Overview
Product name
Anti-Angiopoietin 1 antibody [171718]
See all Angiopoietin 1 products (6) ...
Description
Mouse monoclonal [171718] to Angiopoietin 1
Specificity
This antibody shows no cross-reactivity with recombinant human angiopoietin-2, recombinant human angiopoietin-4, recombinant mouse angiopoietin-like 3, and recombinant human cornea-derived transcript 6 (CDT-6).
Tested applications
Indirect ELISA, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Purified, recombinant, full length human Angiopoietin 1, NSO-derived
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 5% Trehalose, PBS
Endotoxin level is < 0.1 E.U. (endotoxin units) /µg antibody as determined by the LAL method.
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
171718
Myeloma
unknown
Isotype
IgG2b
Research areas
Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Angiogenesis >> Growth Factors >> Angiopoietin
Applications
Show applications key
Our Abpromise guarantee covers the use of ab49694 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
I-ELISA: Use a concentration of 0.5 - 1.0 µg/ml.
WB: Use a concentration of 1 - 2 µg/ml.Predicted molecular weight: 58 kDa.
Target
Function
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
Sequence similarities
Contains 1 fibrinogen C-terminal domain.
Post-translational
modifications
Glycosylated.
Cellular localization
Secreted.
Target information above from: UniProt accessionQ15389
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AGP 1 antibody
- AGP1 antibody
- AGPT antibody
see all
Database links
- Entrez Gene: 284 Human
- Omim: 601667 Human
- SwissProt: Q15389 Human
- Unigene: 369675 Human
References for Anti-Angiopoietin 1 antibody [171718] (ab49694)
ab49694 has not yet been referenced specifically in any publications.
Publishing research using ab49694? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"