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Anti-Angiotensin Converting Enzyme 1 antibody [2E2] (ab11734)

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Overview

Product name

Anti-Angiotensin Converting Enzyme 1 antibody [2E2]
See all Angiotensin Converting Enzyme 1 products (17) ...

Description

Mouse monoclonal [2E2] to Angiotensin Converting Enzyme 1

Specificity

Ab11734 recognises human Angiotensin Converting Enzyme.

Tested applications

IHC-P, ELISA, WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Rabbit, Guinea pig, Cow, Cat, Dog, Human, Monkey

Immunogen

Denatured Human kidney Angiotensin Converting Enzyme.

Epitope

This clone recognises denatured ACE, binding to an epitope in the C domain, and has been reported to be active in Western blotting.

Positive control

For immunohistology use kidney tissue (lung in rat studies).

General notes

This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.09% Sodium Azide

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

2E2

Myeloma

x63-Ag8.653

Isotype

IgG1

Research areas

Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Vasculature >> Vasoconstriction >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ACEs
Signal Transduction >> Metabolism >> Vitamins / Minerals
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Cardiovascular >> Blood >> Serum Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab11734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    IHC-P

     IHC-P: Use at an assay d...Read more →

    IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.(Use neat - 1/20.)

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    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

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    WB

     WB: 1/50 - 1/100.(Predic...Read more →

    WB: 1/50 - 1/100.(Predicted molecular weight: 170 (somatic) or 90 (germinal) kDa.)

Target

Relevance

ACE converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilatator. ACE exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.

Cellular localization

Cell Membrane

Alternative names

  • ACE 1 antibody
  • ACE antibody
  • ACE T antibody
  • ACE1 antibody
  • Angiotensin converting enzyme somatic isoform antibody
  • Angiotensin converting enzyme testis specific isoform antibody
  • Angiotensin I converting enzyme antibody
  • Angiotensin I converting enzyme 1 antibody
  • Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody
  • Carboxycathepsin antibody
  • CD 143 antibody
  • CD143 antibody
  • CD143 antigen antibody
  • DCP 1 antibody
  • DCP antibody
  • DCP1 antibody
  • Dipeptidyl carboxypeptidase 1 antibody
  • Kininase II antibody
  • MGC26566 antibody
  • MVCD3 antibody
  • Peptidase P antibody
  • Peptidyl dipeptidase A antibody
  • Testicular ECA antibody
see all

Database links

see all

References for Anti-Angiotensin Converting Enzyme 1 antibody [2E2] (ab11734)

This product has been referenced in:

  • Fraccarollo Det al. Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation 123:400-8 (2011). WB; Mouse.Read more (PubMed: 21242479) »
  • Sodhi Ket al. CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. Hypertension 56:871-8 (2010). WB; Rat.Read more (PubMed: 20837888) »

See all 6 publications for this product

Publishing research using ab11734? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"