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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-Angiotensin Converting Enzyme 1 antibody [M4110421]
See all Angiotensin Converting Enzyme 1 products (17) ...
Description
Mouse monoclonal [M4110421] to Angiotensin Converting Enzyme 1
Specificity
Shown to crossreact with human, bovine and mouse Angiotensin Converting Enzyme and Endothelial cells.
Tested applications
ELISA, Flow Cyt, IHC-Fr, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Cow, Human
Immunogen
Human Angiotensin Converting Enzyme
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purification notes
Purified by PEG precipitation.
Clonality
Monoclonal
Clone number
M4110421
Isotype
IgM
Research areas
Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Vasculature >> Vasoconstriction >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ACEs
Signal Transduction >> Metabolism >> Vitamins / Minerals
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Cardiovascular >> Blood >> Serum Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2092 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
Flow Cyt: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
IHC-P: Use at an assay dependent dilution.
Target
Relevance
ACE converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilatator. ACE exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.
Cellular localization
Cell Membrane
Alternative names
- ACE 1 antibody
- ACE antibody
- ACE T antibody
see all
Database links
- Entrez Gene: 509484 Cow
- Entrez Gene: 1636 Human
- Entrez Gene: 11421 Mouse
- Omim: 106180 Human
- SwissProt: P12821 Human
- SwissProt: P09470 Mouse
- Unigene: 298469 Human
References for Anti-Angiotensin Converting Enzyme 1 antibody [M4110421] (ab2092)
ab2092 has not yet been referenced specifically in any publications.
Publishing research using ab2092? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"