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Products:Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ACEs
Overview
Product name
Anti-Angiotensin Converting Enzyme 2 antibody
See all Angiotensin Converting Enzyme 2 products (14) ...
Description
Rabbit polyclonal to Angiotensin Converting Enzyme 2
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: CRANHYEDYGDYWRGDYE, corresponding to Internal sequence amino acids 192-208 of Human ACE2. (Peptide available as ab15351.)
CRANHYEDYG DYWRGDYE
Positive control
Human kidney or human testis cell lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 0.02% sodium azide
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Primary antibody notes
Has no cross reactivity to ACE1.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Vasculature >> Vasoconstriction >> Other
Cardiovascular >> Heart >> Contractility >> Inotropics
Cardiovascular >> Blood >> Blood Pressure regulation
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ACEs
Applications
Show applications key
Our Abpromise guarantee covers the use of ab15347 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use a concentration of 2 µg/ml
WB: Use a concentration of 0.5 - 2 µg/ml.Detects a band of approximately 90 kDa (predicted molecular weight: 97 kDa).Can be blocked with Angiotensin Converting Enzyme 2 peptide (192 - 208) (ab15351).
Target
Function
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Tissue specificity
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
Sequence similarities
Belongs to the peptidase M2 family.
Post-translational
modifications
N-glycosylation on Asn-90 may limit SARS infectivity.
Cellular localization
Secreted and Cell membrane.
Target information above from: UniProt accessionQ9BYF1
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ACE 2 antibody
- ACE related carboxypeptidase antibody
- ACE-related carboxypeptidase antibody
see all
Database links
- Entrez Gene: 59272 Human
- Omim: 300335 Human
- SwissProt: Q9BYF1 Human
- Unigene: 178098 Human
Anti-Angiotensin Converting Enzyme 2 antibody images:
Western blot - Angiotensin Converting Enzyme 2 antibody (ab15347)
Lane 1 : Anti-Angiotensin Converting Enzyme 2 antibody (ab15347) at 0.5 µg/ml
Lane 2 : Anti-Angiotensin Converting Enzyme 2 antibody (ab15347) at 1 µg/ml
Lane 3 : Anti-Angiotensin Converting Enzyme 2 antibody (ab15347) at 2 µg/ml
Lane 1 : Human kidney lysate
Lane 2 : Human kidney lysate
Lane 3 : Human kidney lysate
Predicted band size : 97 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Angiotensin Converting Enzyme 2 antibody (ab15347)
ab15347 at 2µg/ml staining Angiotensin Converting Enzyme 2 by IHC
References for Anti-Angiotensin Converting Enzyme 2 antibody (ab15347)
ab15347 has not yet been referenced specifically in any publications.
Publishing research using ab15347? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"