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Anti-Angiotensin Converting Enzyme 2 antibody (ab87436)

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Overview

Product name

Anti-Angiotensin Converting Enzyme 2 antibody
See all Angiotensin Converting Enzyme 2 products (14) ...

Description

Rabbit polyclonal to Angiotensin Converting Enzyme 2

Tested applications

WB, IHC-Pmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat, Hamster, Cat, Dog, Orangutan

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 350 - 450 of Human Angiotensin Converting Enzyme 2.

(Peptide available as ab87437.)

Positive control

This antibody gave a positive signal in the following tissue lysate: Human Kidney

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - Angiotensin Converting Enzyme 2 antibody (ab87436)Western blot - Angiotensin Converting Enzyme 2 antibody (ab87436) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab87436 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Tissue specificity

Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.

Sequence similarities

Belongs to the peptidase M2 family.

Post-translational
modifications

N-glycosylation on Asn-90 may limit SARS infectivity.

Cellular localization

Secreted and Cell membrane.

Target information above from: UniProt accessionQ9BYF1 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ACE 2 antibody
  • ACE related carboxypeptidase antibody
  • ACE-related carboxypeptidase antibody
  • ACE2 antibody
  • ACE2_HUMAN antibody
  • ACEH antibody
  • Angiotensin converting enzyme 2 antibody
  • Angiotensin converting enzyme homolog antibody
  • Angiotensin converting enzyme like protein antibody
  • Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2 antibody
  • Angiotensin I converting enzyme 2 antibody
  • Angiotensin-converting enzyme homolog antibody
  • DKFZP434A014 antibody
  • EC 3.4.17 antibody
  • metalloprotease MPROT 15 antibody
  • Metalloprotease MPROT15 antibody
  • OTTHUMP00000022963 antibody
  • Processed angiotensin-converting enzyme 2 antibody
see all

Anti-Angiotensin Converting Enzyme 2 antibody images:

  Western blot - Angiotensin Converting Enzyme 2 antibody (ab87436)

Western blot - Angiotensin Converting Enzyme 2 antibody (ab87436)

Anti-Angiotensin Converting Enzyme 2 antibody (ab87436) at 1 µg/ml + Kidney (Human) Tissue Lysate - adult normal tissue (ab30203) at 10 µg

Secondary
Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
developed using the ECL technique

Performed under reducing conditions.

Predicted band size : 92 kDa
Observed band size : 92 kDa
Additional bands at : 115 kDa (possible glycosylated form).

Exposure time : 30 seconds

ACE 2 contains multiple glycosylation sites (SwissProt) which may account for the characteristic reaction observed around the predicted molecular weight.

References for Anti-Angiotensin Converting Enzyme 2 antibody (ab87436)

ab87436 has not yet been referenced specifically in any publications.

Publishing research using ab87436? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"