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- Secondary antibodies
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Product name
Anti-Angiotensin II Type 1 Receptor antibody
See all Angiotensin II Type 1 Receptor products (11) ...
Description
Sheep polyclonal to Angiotensin II Type 1 Receptor
Specificity
This antibody is specific for the Angiotensin II Type-1 Receptor.
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Mouse, Rat
Immunogen
Fusion protein Angiotensin II Type-1 receptor.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Phosphate buffered saline
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Metabolism >> Types of disease >> Cancer
Cancer >> Cancer Metabolism >> Cellular metabolic process
Cardiovascular >> Blood >> Blood Pressure regulation
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1886 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent concentration.
WB: Use at an assay dependent concentration.
Target
Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Tissue specificity
Liver, lung, adrenal and adrenocortical adenomas.
Involvement in disease
Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Post-translational
modifications
C-terminal Ser or Thr residues may be phosphorylated.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP30556
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AG2S antibody
- Agtr 1 antibody
- Agtr1 antibody
see all
Database links
- Entrez Gene: 11607 Mouse
- Entrez Gene: 11608 Mouse
- Entrez Gene: 24180 Rat
- Entrez Gene: 81638 Rat
- SwissProt: P29754 Mouse
- SwissProt: P29755 Mouse
- SwissProt: P25095 Rat
- SwissProt: P29089 Rat
References for Anti-Angiotensin II Type 1 Receptor antibody (ab1886)
This product has been referenced in:
- Ramkhelawon B et al. Shear stress regulates angiotensin type 1 receptor expression in endothelial cells. Circ Res 105:869-75 (2009).Read more (PubMed: 19762680) »
- Cook JL et al. Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation. J Mol Cell Cardiol 40:696-707 (2006).Read more (PubMed: 16516913) »
See all 2 publications for this product
Publishing research using ab1886? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"