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Overview

  • Product nameAnti-Anillin antibodySee all Anillin primary antibodies ...
  • Description
    Goat polyclonal to Anillin
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Dog
  • Immunogen

    Synthetic peptide: C-TYPDDEKRKNP, corresponding to internal sequence amino acids 1018-1028 of Human Anillin

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlHuman or mouse Brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab52059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
ELISA
  • Application notesPeptide ELISA: Antibody detection limit dilution 1:16,000.
    WB: Use at a concentration of 1.0 - 3.0 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 124 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionRequired for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression.
    • Tissue specificityUbiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
    • Sequence similaritiesContains 1 PH domain.
    • Developmental stageExpressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus. In dividing cells expression increases during S and G2 phases, peaks at mitosis and subsequently drops as cells enter G1 phase.
    • Post-translational
      modifications      Phosphorylated during mitosis.
      Ubiquitinated, and this requires FZR1/CDH1.
    • Cellular localizationNucleus. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.

      • Target information above from: UniProt accession Q9NQW6 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          Actin binding protein scraps homolog Drosophila antibodyActin binding protein anillin antibodyActin-binding protein anillin antibody
          Anillin actin binding protein antibodyANLN antibodyANLN_HUMAN antibodyDKFZp779A055 antibodyScra antibodyScraps antibodyScraps homolog antibody
        see all

      Anti-Anillin antibody images

      References for Anti-Anillin antibody (ab52059)

      ab52059 has not yet been referenced specifically in any publications.

      Publishing research using ab52059 ? Please let us know so that we can cite the reference in this datasheet

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