Overview

  • Product nameAnti-Anillin antibodySee all Anillin primary antibodies ...
  • Description
    Goat polyclonal to Anillin
  • Tested applicationsWB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Dog
  • Immunogen

    Synthetic peptide:

    C-TYPDDEKRKNP

    , corresponding to internal sequence amino acids 1018-1028 of Human Anillin

  • Positive control
    • Human or mouse Brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab52059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Antibody detection limit dilution 1:16,000.
    WB: Use at a concentration of 1.0 - 3.0 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 124 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRequired for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression.
    • Tissue specificityUbiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
    • Sequence similaritiesContains 1 PH domain.
    • Developmental stageExpressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus. In dividing cells expression increases during S and G2 phases, peaks at mitosis and subsequently drops as cells enter G1 phase.
    • Post-translational
      modifications
      Phosphorylated during mitosis.
      Ubiquitinated, and this requires FZR1/CDH1.
    • Cellular localizationNucleus. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
    • Information by UniProt
    • Database links
    • Alternative names
      • Actin binding protein scraps homolog Drosophila antibody
      • Actin binding protein anillin antibody
      • Actin-binding protein anillin antibody
      • Anillin actin binding protein antibody
      • ANLN antibody
      • ANLN_HUMAN antibody
      • DKFZp779A055 antibody
      • Scra antibody
      • Scraps antibody
      • Scraps homolog antibody
      see all

    Anti-Anillin antibody images

    References for Anti-Anillin antibody (ab52059)

    ab52059 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"