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Read our guarantee »Overview
Product name
Anisomycin
Description
Protein synthesis inhibitor
Biological description
Translational inhibitor of protein synthesis. Highly potent activator of kinase cascades. Potently activates stress-activated protein kinases, p38, JNK MAP and other kinases.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Country restrictions and/or license requirements may apply. Please contact customer services for further details.
Properties
Chemical name
(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
Molecular Weight
265.31
Chemical structure
Molecular formula
C14H19NO4
CAS Number
22862-76-6
Solubility
Soluble in DMSO to 100 mM and in ethanol to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> MAP kinase >> Activators
Biochemicals >> Pharmacology >> Signaling >> DNA, RNA & protein synthesis >> Inhibitors
Biochemicals >> Chemical Type >> Antibiotic
Biochemicals >> Chemical Type >> Biochemicals
References for Anisomycin (ab120495)
This product has been referenced in:
- Croons V et al. The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase. J Pharmacol Exp Ther 329:856-64 (2009).Read more (PubMed: 19286921) »
- Xiong W et al. Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex. Brain Res 1085:68-76 (2006).Read more (PubMed: 16581040) »
See all 3 publications for this product
Publishing research using ab120495? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"