Anti-Antithrombin III antibody [8D5] (ab117851)

Overview

• Product nameAnti-Antithrombin III antibody [8D5]See all Antithrombin III primary antibodies ...
• Description
  Mouse monoclonal [8D5] to Antithrombin III
• Tested applicationsFlow Cyt, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length recombinant Human Antithrombin III (NP_000479) produced in HEK293T cells.

• Positive controlHEK293T transfected cells

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferpH: 7.30
  Preservative: 0.02% Sodium azide
  Constituents: 1% BSA, 50% Glycerol, 48% PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified from mouse ascite fluid by affinity chromatography
• Clonality Monoclonal
• Clone number8D5
• IsotypeIgG2b
• Research Areas
  • Cardiovascular
  • Blood
  • Coagulation
  • Regulatory

  • Cardiovascular
  • Blood
  • Serum Proteins

Applications

Target

• FunctionMost important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
• Tissue specificityFound in plasma.
• Involvement in diseaseDefects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
• Sequence similaritiesBelongs to the serpin family.
• Post-translational
  modificationsPhosphorylation sites are present in the extracelllular medium.
• Cellular localizationSecreted > extracellular space.

Target information above from: UniProt accession P01008 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 462 Human
  • Omim: 107300 Human
  • SwissProt: P01008 Human
  • Unigene: 75599 Human

• Alternative names
  ANT3_HUMAN antibodyAntithrombin antibodyAntithrombin III antibody

  Antithrombin-III antibodyAntithrombinIII antibodyAT 3 antibodyAT III antibodyAT3 antibodyAT3D antibodyATIII antibodyMGC22579 antibodySerine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibodySerine cysteine proteinase inhibitor clade C member 1 antibodySerine proteinase inhibitor clade C member 1 antibodySerpin C1 antibodySerpin peptidase inhibitor clade C (antithrombin) member 1 antibodySERPINC1 antibodyTHPH7 antibody

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Anti-Antithrombin III antibody [8D5] images

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  Flow Cytometry - Anti-Antithrombin III antibody [8D5] (ab117851)
  Flow cytometry image using ab117851 at a 1/100 dilution, staining HEK293T cells transfected with Antithrombin III (Red), or an empty vector control plasmid (Blue).