Overview

  • Product name
    Apamin
  • Description
    Blocker of small conductance Ca2+-activated K+ channels
  • Biological description
    Peptide neurotoxin that naturally occurs in Apis mellifera bee venom. Blocks small conductance Ca2+ activated K+ channels (SK). Selective for KCa2.1-2.3 (SK1-3) isoforms. Blocks hSK1, rSK2 and liver rSK3 (IC50 values are 8 nM, 83 pM and 0.6 nM, respectively).
  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Barfod ET  et al. Cloning and functional expression of a liver isoform of the small conductance Ca2+-activated K+ channel SK3. Am J Physiol Cell Physiol 280:C836-42 (2001). Read more (PubMed: 11245600) »
  • Shah M & Haylett DG The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol 129:627-30 (2000). Read more (PubMed: 10683185) »
  • Strøbaek D  et al. Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol 129:991-9 (2000). Read more (PubMed: 10696100) »

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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