You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameApamin
  • Description
    Blocker of small conductance Ca2+-activated K+ channels
  • Biological descriptionPeptide neurotoxin that naturally occurs in Apis mellifera bee venom. Blocks small conductance Ca2+ activated K+ channels (SK). Selective for KCa2.1-2.3 (SK1-3) isoforms. Blocks hSK1, rSK2 and liver rSK3 (IC50 values of 8 nM, 83 pM and 0.6 nM respectively).
  • Purity> 95%

    • Properties

  • Chemical nameCNCKAPETALCARRCQQH-NH2 (Disulfide bridge 1-11, 3-15)
  • Molecular Weight2027.35
  • Chemical structureChemical Structure
  • Molecular formulaC79H131N31O24S4
  • CAS Number24345-16-2
  • PubChem identifier16218850
  • Storage instructionsStore at -20°C (desiccating conditions).
  • Solubility overviewSoluble in water
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • Source

    Synthetic

  • Research Areas

    • References for Apamin (ab120268)

    This product has been referenced in:
    • Barfod ET  et al. Cloning and functional expression of a liver isoform of the small conductance Ca2+-activated K+ channel SK3. Am J Physiol Cell Physiol 280:C836-42 (2001). Read more (PubMed: 11245600) »
    • Shah M & Haylett DG The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol 129:627-30 (2000). Read more (PubMed: 10683185) »
    • Strøbaek D  et al. Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol 129:991-9 (2000). Read more (PubMed: 10696100) »

    See all 2 Publications for this product

    Publishing research using ab120268 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit a Question for ab120268

    There are currently no Questions for ab120268.
    Please use the link above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"