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Western blot - Aph 1b antibody (ab24613)
(enlarge)
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Product Name
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Aph 1b antibody
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See all Aph 1b antibodies (2)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Aph 1b
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Immunogen
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Synthetic peptide (Human), containing the C terminal sequence of human Aph 1B.
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Reacts with
(species key)
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Hu
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Specificity
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This antibody reacts with Aph-1b, and also shows some cross reactivity with
Aph-1aL/S.
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Epitope
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This antibody recognises sequence CQDKNFLLYNQRSRQDKNFLLYNQRSR of human Aph-1b.
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Tested applications
(see key)
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ICC/IF, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IF: 1/1000.
WB: 1/1000. Predicted molecular weight: 28 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Integral membrane protein.
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Research areas
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Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Amyloid
Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Other
Neuroscience >> Neurology process >> Notch Pathway
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Relevance
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The gamma secretase is a multiprotein complex consisting of presenilin,nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic activity. The gamma secretase complex catalyzes cleavage of a number of integral membrane proteins including Amyloid precursor protein, Notch, Erb4 and E-cadherin. While Aph-1 stabilizes the presenilin holoprotein within the gamma secretase complex, Pen-2 is required for endoproteolysis of presenilin and activation of the gamma secretase. The Aph-1 homologue on human chromosome 1 is termed Aph-1a and on human chromosome 15 is referred to as Aph-1b.
This antibody recognizes a sequence in the Aph-1b C-Terminal Region.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 83464 (Human)
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.005% Sodium Azide
Constituents: PBS, Glycerol (16.6% final volume), 1mg/ml BSA Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.700 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Aph 1b antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for Aph 1b antibody images, references, products related to ab24613 and other tools.
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Aph 1b antibody images:
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 Western blot - Aph 1b antibody (ab24613)
Predicted band size : 28 kDa
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Search PubMed (MEDLINE) for references to Aph 1b
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Aph 1b antibody - more information
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Customer reviews (feedback) regarding Aph 1b antibody |
Customer FAQs regarding Aph 1b antibody |
Protocols for Aph 1b antibody |
Price and availability of products related to Aph 1b antibody |
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Aph 1b antibody - related products:
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Aph 1b antibody - other tools:
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Contact Abcam with a Technical Enquiry about Aph 1b antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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