Anti-Apolipoprotein A II antibody (ab7615)
Overview
- Product nameAnti-Apolipoprotein A II antibodySee all Apolipoprotein A II primary antibodies ...
- DescriptionGoat polyclonal to Apolipoprotein A II
- SpecificityTypically less than 1% cross reactivity against other types of apoLipoprotein was detected by ELISA. This antibody reacts with human apoLipoprotein A-II and has negligible cross-reactivity with Type A-I, B, C-I, C-II, C-III, E and J apoLipoproteins.
- Tested applicationsDot Blot, ELISA, WB more details
- Species reactivityReacts with: Human
- Immunogen
Full length native apoLipoprotein Type A-II (purified).
- General notesThis antibody has been used to determine that atherosclerotic lesions in the human aorta contain considerable amounts of lipoproteins. These lipoproteins were observed to be complexed with components of the extracellular matrix (especially LDL and proteoglycans). The role of these matrix-lipoprotein complexes is not entirely clear, however, animal models of atherosclerosis have shown that increased cellular proliferation and increased production of extracellular matrix components occur following injury to the intimal layer of the aorta.
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.01% Sodium Azide
Constituents: 0.125M Sodium Borate, 0.075M Sodium Chloride, 0.005M EDTA. pH 8 -
Concentration information loading... - PurityImmunogen affinity purified
- Purification notesThis product has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other apoLipoproteins and human serum proteins to remove any unwanted specificities.
- Clonality Polyclonal
- IsotypeIgG
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Research Areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Applications
Our Abpromise guarantee covers the use of ab7615 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| Dot Blot | Dot: 1/5000 - 1/10000. |
| ELISA | ELISA: 1/4000 - 1/8000. |
| WB | WB: Use at an assay dependent dilution. |
Target
- FunctionMay stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
- Tissue specificityPlasma; synthesized in the liver and intestine.
- Sequence similaritiesBelongs to the apolipoprotein A2 family.
- Post-translational
modificationsPhosphorylation sites are present in the extracelllular medium. - Cellular localizationSecreted.
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Database links
- Entrez Gene: 336 Human
- Entrez Gene: 336 Human
- Omim: 107670 Human
- SwissProt: P02652 Human
- SwissProt: P02652 Human
- Unigene: 237658 Human
Target information above from: UniProt accession
P02652
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- APO A2 antibodyApo AII antibodyApo-AII antibody
- APOA 2 antibodyApoA II antibodyApoA-II antibodyAPOA2 antibodyAPOA2_HUMAN antibodyAPOAII antibodyApolipoprotein A II antibodyApolipoprotein A-II(1-76) antibodyApolipoprotein A2 antibodyApolipoprotein AII antibodyApolipoproteinA II antibodyOTTHUMP00000032244 antibody
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References for Anti-Apolipoprotein A II antibody (ab7615)
This product has been referenced in:
- Kasthuri RS et al. Extraordinary apolipoprotein oxidation in chronic hepatitis C and liver cirrhosis. Mol Cell Proteomics : (2007). WB ; Human . Read more (PubMed: 17709793) »
