Anti-Apolipoprotein B antibody (ab13993)

Overview

• Product nameAnti-Apolipoprotein B antibodySee all Apolipoprotein B primary antibodies ...
• Description
  Chicken polyclonal to Apolipoprotein B
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length protein (Human).

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPeptide immunogen affinity column.
• Clonality Polyclonal
• IsotypeIgY
• Research Areas
  • Metabolism
  • Types of disease
  • Heart disease

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Cholesterol Metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Cardiovascular
  • Atherosclerosis
  • Thrombosis
  • Fibrinolysis

  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipid Metabolism
  • Cholesterol Metabolism

  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipoproteins/Apolipoproteins
  • Apolipoproteins

Applications

Target

• FunctionApolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
• Involvement in diseaseFamilial hypobetalipoproteinemia 1 (FHBL1) [MIM:107730]: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Note=The disease is caused by mutations affecting the gene represented in this entry.
  Familial ligand-defective apolipoprotein B-100 (FDB) [MIM:144010]: Dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Note=The disease is caused by mutations affecting the gene represented in this entry.
  Note=Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.
• Sequence similaritiesContains 1 vitellogenin domain.
• Post-translational
  modificationsPalmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.
• Cellular localizationCytoplasm. Secreted.

Target information above from: UniProt accession P04114 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 338 Human
  • Omim: 107730 Human
  • SwissProt: P04114 Human
  • Unigene: 120759 Human

• Alternative names
  Apo B 100 antibodyApo B antibodyApo B-100 antibody

  Apo B-48 antibodyApoB 100 antibodyApoB 48 antibodyApoB antibodyAPOB protein antibodyAPOB_HUMAN antibodyApolipoprotein B 100 antibodyApolipoprotein B 48 antibodyApolipoprotein B antibodyApolipoprotein B-48 antibodyApolipoprotein B48 antibodyFLDB antibodyLDLCQ4 antibody

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