Anti-Apolipoprotein CI antibody (Biotin) (ab27634)
Overview
- Product nameAnti-Apolipoprotein CI antibody (Biotin)See all Apolipoprotein CI primary antibodies ...
- DescriptionGoat polyclonal to Apolipoprotein CI (Biotin)
- ConjugationBiotin
- SpecificitySpecifically binds to human Apolipoprotein C-I.
- Tested applicationsWB, ELISA more details
- Species reactivityReacts with: Human
- Immunogen
Full length native Apo CI protein (purified) (Human)
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
- Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, 75mM Sodium chloride, 75mM PBS, pH 7.2 -
Concentration information loading... - PurityImmunogen affinity purified
- Purification notesPurified by human Apolipoprotein C-I-SepharoseTM affinity column.
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab27634 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | WB: 1/200 - 1/8000. Predicted molecular weight: 9 kDa. The antibody can be used to detect human Apolipoprotein CIII in plasma, immunoassays and immunoblots. |
| ELISA | ELISA: 1/200 - 1/8000. |
Target
- RelevanceThe protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).
- Cellular localizationSecreted
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Database links
- Entrez Gene: 341 Human
- Omim: 107710 Human
- SwissProt: P02654 Human
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Alternative names
- APO C1 antibody
- Apo CI antibody
- Apo-CIB antibody
- Apo-CIB' antibody
- APOC 1 antibody
- ApoC I antibody
- ApoC-IB antibody
- ApoC-IB' antibody
- APOC1 antibody
- APOC1B antibody
- Apolipoprotein C I antibody
- Apolipoprotein C-I antibody
- Apolipoprotein CI antibody
- ApolipoproteinC I antibody
- ApolipoproteinCI antibody
- Truncated apolipoprotein C-I antibody
see all
References for Anti-Apolipoprotein CI antibody (Biotin) (ab27634)
This product has been referenced in:
- Dernick G et al. Multidimensional profiling of plasma lipoproteins by size exclusion chromatography followed by reverse-phase protein arrays. J Lipid Res 52:2323-31 (2011). Read more (PubMed: 21971713) »
