Anti-Apolipoprotein CI antibody (FITC) (ab27645)

Overview

• Product nameAnti-Apolipoprotein CI antibody (FITC)See all Apolipoprotein CI primary antibodies ...
• Description
  Goat polyclonal to Apolipoprotein CI (FITC)
• ConjugationFITC
• Conjugation notesMolar F/P ratio is 3.4.
• SpecificityThis antibody specifically binds to Apolipoprotein C-I.
• Tested applicationsICC/IF more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide ApoCI (Human)

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 5mg/ml BSA, 75mM Sodium chloride, 75mM PBS, 0.5mM EDTA. pH 7.4
• Concentration information loading...
• PurityProtein G purified
• Purification notesThis antibody was purified by human Apolipoprotein C-I Sepharose affinity column.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Types of disease
  • Heart disease

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Fatty acid oxidation

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Fatty acids

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipoprotein metabolism

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Cardiovascular
  • Atherosclerosis
  • Lipoprotein metabolism

  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipoproteins/Apolipoproteins
  • Lipoproteins

  • Cardiovascular
  • Lipids / Lipoproteins
  • Fatty Acids
  • Binding proteins

Applications

Target

• RelevanceThe protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).
• Cellular localizationSecreted
• Database links
  • Entrez Gene: 341 Human
  • Entrez Gene: 341 Human
  • Omim: 107710 Human
  • SwissProt: P02654 Human
  • SwissProt: P02654 Human

• Alternative names
  APO C1 antibodyApo CI antibodyApo-CIB antibody

  Apo-CIB' antibodyAPOC 1 antibodyApoC I antibodyApoC-IB antibodyApoC-IB' antibodyAPOC1 antibodyAPOC1B antibodyApolipoprotein C I antibodyApolipoprotein C-I antibodyApolipoprotein CI antibodyApolipoproteinC I antibodyApolipoproteinCI antibodyTruncated apolipoprotein C-I antibody

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