Anti-Apolipoprotein CI antibody (ab104446)

Overview

• Product nameAnti-Apolipoprotein CI antibodySee all Apolipoprotein CI primary antibodies ...
• Description
  Goat polyclonal to Apolipoprotein CI
• Specificityab104446 recognizes Human Apolipoprotein CI in plasma and lipoproteins. It does not cross-react with plasma Apo A-I, Apo A-II, Apo B-100, Apo C-II, Apo C-III and Apo-E.
• Tested applicationsWB, ELISA, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length native protein (purified) (Human)

• Positive controlHuman Liver tissue

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 40% Glycerol, PBS, 0.5mM EDTA, pH 7.2
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Heart disease

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Fatty acid oxidation

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipoprotein metabolism

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Fatty acids

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipoproteins/Apolipoproteins
  • Lipoproteins

  • Cardiovascular
  • Lipids / Lipoproteins
  • Fatty Acids
  • Binding proteins

  • Cardiovascular
  • Atherosclerosis
  • Lipoprotein metabolism

Applications

Target

• RelevanceThe protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).
• Cellular localizationSecreted
• Database links
  • Entrez Gene: 341 Human
  • Entrez Gene: 341 Human
  • Omim: 107710 Human
  • SwissProt: P02654 Human
  • SwissProt: P02654 Human

• Alternative names
  APO C1 antibodyApo CI antibodyApo-CIB antibody

  APOC 1 antibodyApoC I antibodyApoC-IB antibodyAPOC1 antibodyAPOC1B antibodyApolipoprotein C I antibodyApolipoprotein C-I antibodyApolipoprotein CI antibodyApolipoproteinC I antibodyApolipoproteinCI antibodyTruncated apolipoprotein C-I antibody

  see all

Anti-Apolipoprotein CI antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Apolipoprotein CI antibody (ab104446)
  ab104446, at 5 ug/ml, staining Apolipoprotein CI in formalin-fixed, paraffin-embedded Human Liver by Immunohistochemistry, using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.