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Overview

Applications

Our Abpromise guarantee covers the use of ab54800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • RelevanceThe protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).
    • Cellular localizationSecreted
    • Database links
      • Alternative names
          APO C1 antibodyApo CI antibodyApo-CIB antibody
          Apo-CIB' antibodyAPOC 1 antibodyApoC I antibodyApoC-IB antibodyApoC-IB' antibodyAPOC1 antibodyAPOC1B antibodyApolipoprotein C I antibodyApolipoprotein C-I antibodyApolipoprotein CI antibodyApolipoproteinC I antibodyApolipoproteinCI antibodyTruncated apolipoprotein C-I antibody
        see all

      Anti-Apolipoprotein CI antibody images

      • Western blot - Apolipoprotein CI antibody (ab54800)
        Western blot - Apolipoprotein CI antibody (ab54800)
        Anti-Apolipoprotein CI antibody (ab54800) at 5 µg/ml + 0.2 µg/lane of full length recombinant protein with a tag

        Secondary
        Goat anti mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

        Predicted band size : 9 kDa
        Observed band size : 35 kDa (why is the actual band size different from the predicted?)
      • Western blot - Apolipoprotein CI antibody (ab54800)
        Western blot - Apolipoprotein CI antibody (ab54800)
        All lanes : Anti-Apolipoprotein CI antibody (ab54800) at 5 µg/ml

        Lane 1 : 50 µg/lane of transfected 293T cell line lysate
        Lane 2 : 50 µg/lane of non-transfected cell line lysate

        Secondary
        Goat anti mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

        Predicted band size : 9 kDa
        Observed band size : 9 kDa

      References for Anti-Apolipoprotein CI antibody (ab54800)

      ab54800 has not yet been referenced specifically in any publications.

      Publishing research using ab54800 ? Please let us know so that we can cite the reference in this datasheet

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"