Overview
- Product nameAnti-Apolipoprotein CI antibodySee all Apolipoprotein CI primary antibodies ...
- DescriptionGoat polyclonal to Apolipoprotein CI
- SpecificityTypically less than 1% cross reactivity against other types of apoLipoprotein was detected by ELISA. This antibody reacts with human apoLipoprotein C-I and has negligible cross-reactivity with Type A-I, A-II, B, C-II, C-III, E and J apoLipoproteins.
- Tested applicationsDot Blot, ELISA, WB more details
- Species reactivityReacts with: Human
- Immunogen
Full length synthetic apoLipoprotein Type C-I (purified).
- General notesThis antibody has been used to determine that atherosclerotic lesions in the human aorta contain considerable amounts of lipoproteins. These lipoproteins were observed to be complexed with components of the extracellular matrix (especially LDL and proteoglycans). The role of these matrix-lipoprotein complexes is not entirely clear, however, animal models of atherosclerosis have shown that increased cellular proliferation and increased production of extracellular matrix components occur following injury to the intimal layer of the aorta.
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.01% Sodium Azide
Constituents: 0.125M Sodium Borate, 0.075M Sodium Chloride, 0.005M EDTA. pH 8 -
Concentration information loading... - PurityImmunogen affinity purified
- Purification notesThis product has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other apoLipoproteins and human serum proteins to remove any unwanted specificities.
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab7617 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| Dot Blot | Dot: 1/5000 - 1/10000. |
| ELISA | ELISA: 1/4000 - 1/8000. |
| WB | WB: 1/1000. |
Target
- RelevanceThe protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).
- Cellular localizationSecreted
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Database links
- Entrez Gene: 341 Human
- Entrez Gene: 341 Human
- Omim: 107710 Human
- SwissProt: P02654 Human
- SwissProt: P02654 Human
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Alternative names
- APO C1 antibodyApo CI antibodyApo-CIB antibody
- Apo-CIB' antibodyAPOC 1 antibodyApoC I antibodyApoC-IB antibodyApoC-IB' antibodyAPOC1 antibodyAPOC1B antibodyApolipoprotein C I antibodyApolipoprotein C-I antibodyApolipoprotein CI antibodyApolipoproteinC I antibodyApolipoproteinCI antibodyTruncated apolipoprotein C-I antibody
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References for Anti-Apolipoprotein CI antibody (ab7617)
ab7617 has not yet been referenced specifically in any publications.
