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Product Name
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Apolipoprotein E antibody (Biotin)
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See all Apolipoprotein E antibodies (14)...
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Product type
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Primary antibodies
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Description
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Goat polyclonal to Apolipoprotein E (Biotin)
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Immunogen
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Purified human Apolipoprotein E from human plasma.
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Reacts with
(species key)
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Hu
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Specificity
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ab24274 binds to Apo E. No cross-reaction to Apo AI, Apo AII, Apo CI, Apo CII, and Apo CIII.
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Tested applications
(see key)
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: 1/5000 - 1/40,000. WB: 1/5000 - 1/40,000. Predicted molecular weight: 36 kDa. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Developmental Biology >> Lineage specification >> Endoderm
Cardiovascular >> Atherosclerosis >> Lipid transport
Signal Transduction >> Metabolism >> Lipid metabolism
Stem Cells >> Lineage Markers >> Endoderm
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
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Relevance
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Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Goat
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: 75mM PBS, 75mM Sodium chloride, 1mM EDTA. pH 7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Purified by human apo E-Sepharose chromatography, then labeled with biotin.
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Form
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Liquid
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Conjugation
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Biotin
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Concentration
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1.200 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Apolipoprotein E antibody (Biotin) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Apolipoprotein E
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Apolipoprotein E antibody (Biotin) - more information
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Customer reviews (feedback) regarding Apolipoprotein E antibody (Biotin) |
Customer FAQs regarding Apolipoprotein E antibody (Biotin) |
Protocols for Apolipoprotein E antibody (Biotin) |
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Apolipoprotein E antibody (Biotin) - other tools:
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