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- Apolipoprotein E antibody [D6E10] (ab1906)
![- Apolipoprotein E antibody [D6E10] (ab1906)](/ps/datasheet/images/ab1906_1.jpg)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Apolipoprotein E antibody [D6E10] (ab1906)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Apolipoprotein E antibody [D6E10] (ab1906)](/ps/datasheet/images/ab1906_2.jpg)
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Western blot - Apolipoprotein E antibody [D6E10] (ab1906)
![Western blot - Apolipoprotein E antibody [D6E10] (ab1906)](/ps/datasheet/images/ab1906_3.jpg)
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Product Name
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Apolipoprotein E antibody [D6E10]
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See all Apolipoprotein E antibodies (14)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [D6E10] to Apolipoprotein E
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Immunogen
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Synthetic peptide spanning the polymorphic amino acid position 158 of ApoE.
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Reacts with
(species key)
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Hu, Ms
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Tested applications
(see key)
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IHC-Fr, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions IHC-P: 1/100 - 1/10000. Antigen retrieval is not essential but may optimise staining. IHC-Fr: 1/100 - 1/10000. WB: 1/100 - 1/1000. Predicted molecular weight: 38 kDa.
Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins Developmental Biology >> Lineage specification >> Endoderm Cardiovascular >> Atherosclerosis >> Lipid transport Signal Transduction >> Metabolism >> Lipid metabolism Stem Cells >> Lineage Markers >> Endoderm Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
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Relevance
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Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.
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Database links
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The links below go to external sites and will open in a new browser window
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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D6E10
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Isotype
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IgG1
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Storage buffer
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Preservative: 0.1% Sodium Azide Constituents: PBS Material safety datasheet (MSDS) for this product: Sodium Azide MSDS
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Purification notes
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Ammonium sulfate precipitated and dialyzed tissue culture supernatant.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Apolipoprotein E antibody [D6E10] is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for Apolipoprotein E antibody [D6E10] images, references, products related to ab1906 and other tools.
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Apolipoprotein E antibody [D6E10] images:
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- Apolipoprotein E antibody [D6E10] (ab1906)
IHC-P using ab1906 showing senile plaques. (x200)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Apolipoprotein E antibody [D6E10] (ab1906)
IHC-P using ab1906. Strong immunoreactivity to Apo E of vascular amyloid ß. Down syndrome. Orig. magn. X 100.
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Western blot - Apolipoprotein E antibody [D6E10] (ab1906)
Predicted band size : 38 kDa
Western blot using ab1906, on 1 µl of human serum
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References for Apolipoprotein E antibody [D6E10] (ab1906)
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This product has been used in: (two most recent references)
Yvan-Charvet L et al. Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL. Arterioscler Thromb Vasc Biol 27:1132-8 (2007). PubMed: 17322101
Ferraro F et al. Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation. Mol Biol Cell 18:4813-25 (2007). WB. PubMed: 17881726
See all 4 publication references for this product.
If you publish research using ab1906 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Apolipoprotein E
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Apolipoprotein E antibody [D6E10] - more information
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Apolipoprotein E antibody [D6E10] - related products:
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Apolipoprotein E antibody [D6E10] - other tools:
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Contact Abcam with a Technical Enquiry about Apolipoprotein E antibody [D6E10] |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"