Apolipoprotein E antibody [D6E10] (ab1906)

Product Name 

Apolipoprotein E antibody [D6E10]

Product type 

Primary antibodies

Description 

Mouse monoclonal [D6E10] to Apolipoprotein E

Immunogen 

Synthetic peptide spanning the polymorphic amino acid position 158 of ApoE.

Reacts with 
(species key)

Hu, Ms

Tested applications 
(see key)

IHC-Fr, IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
IHC-P: 1/100 - 1/10000. Antigen retrieval is not essential but may optimise staining.
IHC-Fr: 1/100 - 1/10000.
WB: 1/100 - 1/1000. Predicted molecular weight: 38 kDa.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Secreted

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Developmental Biology >> Lineage specification >> Endoderm
Cardiovascular >> Atherosclerosis >> Lipid transport
Signal Transduction >> Metabolism >> Lipid metabolism
Stem Cells >> Lineage Markers >> Endoderm
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other

Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other

Relevance 

Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

D6E10

Isotype 

IgG1

Storage buffer 

Preservative: 0.1% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Ammonium sulfate precipitated and dialyzed tissue culture supernatant.

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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References for Apolipoprotein E antibody [D6E10] (ab1906)

  This product has been used in: (two most recent references)

Yvan-Charvet L et al. Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL. Arterioscler Thromb Vasc Biol 27:1132-8 (2007). PubMed: 17322101

Ferraro F et al. Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation. Mol Biol Cell 18:4813-25 (2007). WB. PubMed: 17881726

See all 4 publication references for this product.


If you publish research using ab1906 please let us know so that we can cite the reference on this datasheet.

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