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Anti-Aquaporin 3 antibody (ab15117)

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Overview

Product name

Anti-Aquaporin 3 antibody
See all Aquaporin 3 products (4) ...

Description

Rabbit polyclonal to Aquaporin 3

Tested applications

WB, ELISA, IHC-Frmore details

Cross reactivity

Reacts with

Rat

Predicted to work with

Mouse, Human

Immunogen

Synthetic peptide (Rat) conjugated to KLH (C terminal).

Positive control

Rat kidney medulla or outer cortex.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 40% Glycerol, Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Signal Transduction >> Metabolism >> Plasma Membrane >> Channels

Applications

Show applications key

Our Abpromise guarantee covers the use of ab15117 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.

Tissue specificity

Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Cellular localization

Basolateral cell membrane. In collecting ducts of kidney.

Target information above from: UniProt accessionQ92482 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • AQP 3 antibody
  • AQP-3 antibody
  • Aqp3 antibody
  • AQP3_HUMAN antibody
  • Aquaglyceroporin-3 antibody
  • Aquaporin 3 (GIL blood group) antibody
  • Aquaporin 3 (Gill blood group) antibody
  • Aquaporin-3 antibody
  • Aquaporin3 antibody
  • GIL antibody
  • Gill blood group antibody
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Database links

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References for Anti-Aquaporin 3 antibody (ab15117)

ab15117 has not yet been referenced specifically in any publications.

Publishing research using ab15117? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"