Overview
- Product nameAnti-Aquaporin 4 antibodySee all Aquaporin 4 primary antibodies ...
- DescriptionRabbit polyclonal to Aquaporin 4
- Tested applicationsWB, IHC-P, IHC-Fr more details
- Species reactivityReacts with: Human
- Immunogen
A synthetic peptide from the C terminal region of Human Aquaporin 4 conjugated to an immunogenic carrier protein
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
Constituents: Whole serum, 1X PBS - PurityWhole antiserum
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab85904 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | WB: 1/300 - 1/2000. Predicted molecular weight: 35 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
| IHC-P | IHC-P: 1/300 - 1/2000. |
| IHC-Fr | IHC-Fr: 1/300 - 1/2000. |
Target
- FunctionForms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
- Tissue specificityBrain - muscle >> heart, kidney, lung, and trachea.
- Sequence similaritiesBelongs to the MIP/aquaporin (TC 1.A.8) family.
- DomainAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Post-translational
modificationsPhosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40%. - Cellular localizationMembrane.
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Database links
- Entrez Gene: 361 Human
- Omim: 600308 Human
- SwissProt: P55087 Human
- Unigene: 315369 Human
Target information above from: UniProt accession
P55087
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- AQP 4 antibodyAQP-4 antibodyAQP4 antibody
- AQP4_HUMAN antibodyAquaporin type 4 antibodyAquaporin-4 antibodyAquaporin4 antibodyHMIWC 2 antibodyHMIWC2 antibodyMercurial insensitive water channel antibodyMercurial-insensitive water channel antibodyMGC22454 antibodyMIWC antibodyWCH 4 antibodyWCH4 antibody
see all
References for Anti-Aquaporin 4 antibody (ab85904)
ab85904 has not yet been referenced specifically in any publications.
