Anti-Arg2 antibody (ab88504)

Overview

• Product nameAnti-Arg2 antibodySee all Arg2 primary antibodies ...
• Description
  Mouse polyclonal to Arg2
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length protein, corresponding to amino acids 1-354 of Human Arg2 (AAH29050.1)

• Positive controlCOLO 320 HSR, transfected 293T cell line, human prostate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: PBS, pH 7.2
• Concentration information loading...
• PurityProtein A purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Amino acid metabolism

  • Signal Transduction
  • Metabolism
  • Amino Acids

Applications

Target

• FunctionMay play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
• Tissue specificityExpressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.
• PathwayNitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
• Sequence similaritiesBelongs to the arginase family.
• Cellular localizationMitochondrion.

Target information above from: UniProt accession P78540 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 384 Human
  • Omim: 107830 Human
  • SwissProt: P78540 Human
  • Unigene: 723133 Human
  • Unigene: 226007 Human

• Alternative names
  ARG2 antibodyARGI2_HUMAN antibodyArginase II mitochondrial antibody

  Arginase type II antibodyArginase-2 antibodyarginase-2, mitochondrial antibodyKidney arginase antibodyKidney type arginase antibodyKidney-type arginase antibodyL arginine amidinohydrolase antibodyL arginine ureahydrolase antibodymitochondrial antibodyNon hepatic arginase antibodyNon-hepatic arginase antibodyNonhepatic arginase antibodyType II arginase antibody

  see all

Anti-Arg2 antibody images

• 

  Western blot - Arg2 antibody (ab88504)
  Anti-Arg2 antibody (ab88504) at 5 µg/ml + COLO 320 HSR at 50 µg
  
  Secondary
  HRP goat anti mouse IgG at 1/2500 dilution
  
  Predicted band size : 38 kDa
  
• 

  Western blot - Arg2 antibody (ab88504)
  All lanes : Anti-Arg2 antibody (ab88504) at 5 µg/ml
  
  Lane 1 : transfected 293T cell line
  Lane 2 : non transfected 293T cell line
  
  Lysates/proteins at 25 µg per lane.
  
  Secondary
  HRp goat anti mouse IgG at 1/2500 dilution
  
  Predicted band size : 38 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Arg2 antibody (ab88504)
  Immunohistochemical analysis of Arg2 expression in formalin-fixed paraffin-embedded human prostate using 3ug ab88504