Overview

  • Product nameAnti-Aromatase antibodySee all Aromatase primary antibodies ...
  • Description
    Goat polyclonal to Aromatase
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Cynomolgus Monkey
  • Immunogen

    Synthetic peptide: C-HDLSLHPDETKN, corresponding to internal sequence amino acids 475-486 of Human Aromatase (NP_000094.2; NP_112503.1).

  • Positive control
    • Human Placenta lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
ELISA
  • Application notesPeptide ELISA: Antibody detection limit dilution 1/128000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCatalyzes the formation of aromatic C18 estrogens from C19 androgens.
    • Tissue specificityBrain, placenta and gonads.
    • Involvement in diseaseDefects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.
      Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
    • Sequence similaritiesBelongs to the cytochrome P450 family.
    • Cellular localizationMembrane.
    • Target information above from: UniProt accession P11511 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • ARO 1 antibody
      • ARO antibody
      • ARO1 antibody
      • ARO1 antibody
      • Aromatase antibody
      • CP19A_HUMAN antibody
      • CPV antibody
      • CPV1 antibody
      • CYAR antibody
      • CYP19 antibody
      • CYP19A1 antibody
      • CYPXIX antibody
      • Cytochrome P-450AROM antibody
      • Cytochrome P450 19A1 antibody
      • Cytochrome P450 family 19 subfamily A polypeptide 1 antibody
      • Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody
      • Cytochrome P450, subfamily XIX (aromatization of androgens) antibody
      • Estrogen synthase antibody
      • Estrogen synthetase antibody
      • Flavoprotein linked monooxygenase antibody
      • MGC104309 antibody
      • Microsomal monooxygenase antibody
      • OTTHUMP00000162543 antibody
      • OTTHUMP00000198350 antibody
      • P 450AROM antibody
      • P450AROM antibody
      see all

    Anti-Aromatase antibody images

    • Anti-Aromatase antibody (ab77377) at 0.1 µg/ml + Human Placenta lysate (in RIPA buffer) at 35 µg

      Predicted band size : 58 kDa
      Observed band size : 58 kDa

    References for Anti-Aromatase antibody (ab77377)

    ab77377 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab77377.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"