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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> Helix-Turn-Helix
Overview
Product name
Anti-Aryl hydrocarbon Receptor antibody
See all Aryl hydrocarbon Receptor products (7) ...
Description
Rabbit polyclonal to Aryl hydrocarbon Receptor
Tested applications
Cross reactivity
Reacts with
Mouse, Human
Predicted to work with
Rat, Dog
Immunogen
A region within a synthetic peptide: MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL, corresponding to N terminal amino acids 1-50 of Human Aryl hydrocarbon Receptor
MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL
Positive control
Human placenta.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 2% Sucrose, PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> Helix-Turn-Helix
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Western blot - Aryl hydrocarbon Receptor antibody (ab28698)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab28698 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 2.5 µg/mlDetects a band of approximately 85 kDa.
Target
Function
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.
Tissue specificity
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
Sequence similarities
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
Cellular localization
Cytoplasm. Nucleus. Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
Target information above from: UniProt accessionP35869
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Ah receptor antibody
- AHR antibody
- AHR_HUMAN antibody
see all
Database links
- Entrez Gene: 196 Human
- Entrez Gene: 11622 Mouse
- Entrez Gene: 25690 Rat
- Omim: 600253 Human
- SwissProt: P35869 Human
- SwissProt: P30561 Mouse
- SwissProt: P41738 Rat
- Unigene: 171189 Human
see all
Anti-Aryl hydrocarbon Receptor antibody images:
Western blot - Aryl hydrocarbon Receptor antibody (ab28698)
Anti-Aryl hydrocarbon Receptor antibody (ab28698) at 2.5 µg/ml + Human placental lysate
Secondary
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Observed band size : 85 kDa (why is the actual band size different from the predicted?)
References for Anti-Aryl hydrocarbon Receptor antibody (ab28698)
ab28698 has not yet been referenced specifically in any publications.
Publishing research using ab28698? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"