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Products:Neuroscience >> Cell Type Marker >> Glia marker >> Astrocyte marker
Overview
Product name
Anti-Astrocytomas-low grade antibody [J1-31]
Description
Mouse monoclonal [J1-31] to Astrocytomas-low grade
Specificity
ab80189 recognizes an intracellular protein antigen (MW 30 kDa) expressed by human and rat astrocytes and other specialized glia (Muller cells of the retina, Bergmann fibers of the cerebellar cortex, tanycytes of the hypothalamus and ciliated ependymal cells) in the central nervous system (CNS). ab80189 has recently been found to be a specific marker for low grade astrocytoma in human brain tissue and is able to distinguish between low grade astrocytoma and normal reactive gliosis.
Tested applications
WB, IHC-P, ICCmore details
Cross reactivity
Reacts with
Mouse, Rat, Guinea pig, Human
Immunogen
Tissue / cell preparation - Human cerebral white matter from a multiple sclerosis patient
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Ascites
Concentration
Concentration information loading...
Purity
Ascites
Clonality
Monoclonal
Clone number
J1-31
Isotype
IgM
Research areas
Cancer >> Tumor biomarkers >> Other
Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Other
Tags & Cell Markers >> Cell Type Markers >> Neuroscience Markers >> Glial
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Neuroscience >> Cell Type Marker >> Glia marker >> Astrocyte marker
Applications
Show applications key
Our Abpromise guarantee covers the use of ab80189 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
IHC-P
ICC
Application notes
ICC: Use at an assay dependent dilution.
IHC-P: Use at an assay dependent dilution.
WB: Reducing conditions, recognizes a 30kDa protein. Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
An astrocytoma is a form of glioma tumor which originates in the star-shaped brain cells called astrocytes. There is a four-tiered histologic grading guideline for astrocytomas with the low grade astrocytomas (I & II) being among the least common of all reported brain tumors, less than 6%.
References for Anti-Astrocytomas-low grade antibody [J1-31] (ab80189)
This product has been referenced in:
- Predy Ret al. A new protein (J1-31 antigen, 30 kD) is expressed by astrocytes, Müller glia and ependyma. Biosci Rep 7:491-502 (1987).Read more (PubMed: 3427214) »
See 1 publication for this product
Publishing research using ab80189? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"