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AbcamBiochemicals (Asc-785)

Atipamezole hydrochloride (ab120785)

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Overview

  • Product nameAtipamezole hydrochloride
  • Description
    Selective α2 adrenergic receptor antagonist
  • Biological descriptionSelective α2 adrenergic receptor antagonist. Ki values are 1.1, 1.0, 0.89, 1300 and 8500 nM for adrenergic receptor subtypes α2A, α2B, α2C, α1A and α1B respectively. Centrally active following peripheral administration.
  • Purity> 99%

    • Properties

  • Chemical name5-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride
  • Molecular Weight248.75
  • Chemical structureChemical Structure
  • Molecular formulaC14H16N2.HCl
  • CAS Number104075-48-1
  • Storage instructionsStore at room temperature (desiccating conditions).
  • Solubility overviewSoluble in water to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • Source

    Synthetic

  • Research Areas

    • References for Atipamezole hydrochloride (ab120785)

    This product has been referenced in:
    • Jurgens CW  et al. Alpha2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol Pharmacol 71:1572-81 (2007). Read more (PubMed: 17341653) »
    • Pertovaara A  et al. Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev 11:273-88 (2005). Read more (PubMed: 16389294) »
    • Cordi AA  et al. Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. J Med Chem 44:787-805 (2001). Read more (PubMed: 11262089) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"