Anti-Azurocidin antibody (Biotin) (ab51508)

Overview

• Product nameAnti-Azurocidin antibody (Biotin)See all Azurocidin primary antibodies ...
• Description
  Rabbit polyclonal to Azurocidin (Biotin)
• ConjugationBiotin
• Tested applicationsWB, RIA, Enzyme Immunoassay more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Human Azurocidin

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 50% Glycerol, PBS, pH 7.5
• Concentration information loading...
• PurityProtein G purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Leukocyte recruitment
  • Chemokines

  • Microbiology
  • Antimicrobial
  • Antibiotic

  • Microbiology
  • Protein
  • Human Protein
  • Defensin

  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

Applications

Target

• FunctionThis is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
• Sequence similaritiesBelongs to the peptidase S1 family. Elastase subfamily.
  Contains 1 peptidase S1 domain.
• Cellular localizationCytoplasmic granule. Cytoplasmic granules of neutrophils.

Target information above from: UniProt accession P20160 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 566 Human
  • Omim: 162815 Human
  • SwissProt: P20160 Human
  • Unigene: 72885 Human

• Alternative names
  Azu 1 antibodyAZU1 antibodyAzurocidin antibody

  CAP37 antibodyCAP7_HUMAN antibodyCationic antimicrobial protein 37 antibodyCationic antimicrobial protein CAP37 antibodyHBP antibodyHeparin binding protein antibodyHeparin-binding protein antibodyHUMAZUR antibodyNeutrophil azurocidin antibody

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