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Overview

  • Product nameAnti-B3GAT3 antibodySee all B3GAT3 primary antibodies ...
  • Description
    Rabbit polyclonal to B3GAT3
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (PPLRAAAEQL RQKDLRISQL QAELRRPPPA PAQPPEPEAL PTIYVVTPTY) of Human B3GAT3(NP_036332).

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control721 B Cell Lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab103081 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionGlycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc.
  • Tissue specificityUbiquitous (but weakly expressed in all tissues examined).
  • PathwayProtein modification; protein glycosylation.
  • Involvement in diseaseDefects in B3GAT3 are the cause of multiple joint dislocations short stature craniofacial dysmorphism and congenital heart defects (JDSSDHD) [MIM:245600]. An autosomal recessive disease characterized by dysmorphic facies, bilateral dislocations of the elbows, hips, and knees, clubfeet, and short stature, as well as cardiovascular defects.
  • Sequence similaritiesBelongs to the glycosyltransferase 43 family.
  • Post-translational
    modifications    N-glycosylated.
  • Cellular localizationGolgi apparatus membrane. Golgi apparatus > cis-Golgi network.

    • Target information above from: UniProt accession O94766 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        3-Gal-R glucuronyltransferase antibody3-glucuronyltransferase 3 antibodyB3GA3_HUMAN antibody
        B3GAT3 antibodyBeta 1,3 glucuronyltransferase 3 (glucuronosyltransferase I) antibodyBeta 1,3 glucuronyltransferase 3 antibodyBeta-1 antibodyEC 2.4.1.135 antibodyGalactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 3 antibodyGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 antibodyGlcAT-I antibodyGLCATI antibodyglcUAT I antibodyGlcUAT-I antibodyGlcUATI antibodyGlucuronosyltransferase I antibodySqv 8 like protein antibodyUDP GlcUA:Gal beta 1,3 Gal R glucuronyltransferase antibodyUDP GlcUA:Gal beta 1,3 GalR glucuronyltransferase antibodyUDP-GlcUA:Gal beta-1 antibody
      see all

    Anti-B3GAT3 antibody images

    • Western blot - B3GAT3 antibody (ab103081)
      Western blot - B3GAT3 antibody (ab103081)
      Anti-B3GAT3 antibody (ab103081) at 1 µg/ml + 721 B cell lysate at 10 µg

      Predicted band size : 37 kDa

    References for Anti-B3GAT3 antibody (ab103081)

    ab103081 has not yet been referenced specifically in any publications.

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