Overview

  • Product nameAnti-B4GALT1 antibody
    See all B4GALT1 primary antibodies
  • Description
    Rabbit polyclonal to B4GALT1
  • Tested applicationsIHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen, corresponding to amino acids 323-398 (FRGMSISRPN AVVGRCRMIR HSRDKKNEPN PQRFDRIAHT KETMLSDGLN SLTYQVLDVQ RYPLYTQITV DIGTPS) of Human B4GALT1.

  • Positive control
    • Human lateral ventricle tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab121325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionThe Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
    The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
  • Tissue specificityUbiquitously expressed, but at very low levels in fetal and adult brain.
  • PathwayProtein modification; protein glycosylation.
  • Involvement in diseaseDefects in B4GALT1 are the cause of congenital disorder of glycosylation type 2D (CDG2D) [MIM:607091]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similaritiesBelongs to the glycosyltransferase 7 family.
  • Post-translational
    modifications
    The soluble form derives from the membrane forms by proteolytic processing.
  • Cellular localizationGolgi apparatus > Golgi stack membrane. Cell membrane. Cell surface. Found in trans cisternae of Golgi; Golgi apparatus > Golgi stack membrane. Found in trans cisternae of Golgi and Secreted. Soluble form found in body fluids.
  • Information by UniProt
  • Database links
  • Alternative names
    • 384.Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase antibody
    • 4-galactosyltransferase 1 antibody
    • 4-GalTase 1 antibody
    • b4Gal-T1 antibody
    • B4galt1 antibody
    • B4GT1_HUMAN antibody
    • Beta-1 antibody
    • Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase antibody
    • Beta4Gal-T1 antibody
    • GGTB2 antibody
    • Lactose synthase A protein antibody
    • N-acetyllactosamine synthase antibody
    • Nal synthase antibody
    • Processed beta-1 antibody
    • UDP-Gal:beta-GlcNAc beta-1 antibody
    • UDP-galactose:beta-N-acetylglucosamine beta-1 antibody
    see all

Anti-B4GALT1 antibody images

  • ab121325, at 1/10, staining B4GALT1 in paraffin embedded Human lateral ventricle tissue by Immunohistochemistry.

References for Anti-B4GALT1 antibody (ab121325)

ab121325 has not yet been referenced specifically in any publications.

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