Anti-B4GALT1 antibody (ab121325)

Overview

• Product nameAnti-B4GALT1 antibodySee all B4GALT1 primary antibodies ...
• Description
  Rabbit polyclonal to B4GALT1
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  antigen, corresponding to amino acids 323-398 (FRGMSISRPN AVVGRCRMIR HSRDKKNEPN PQRFDRIAHT KETMLSDGLN SLTYQVLDVQ RYPLYTQITV DIGTPS) of Human B4GALT1.

  Run BLAST with Run BLAST with
• Positive controlHuman lateral ventricle tissue.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferpH: 7.20
  Preservative: 0.02% Sodium azide
  Constituents: 59% PBS, 40% Glycerol
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Developmental Biology
  • Reproduction
  • Fertilisation

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

Applications

Target

• FunctionThe Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
  The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
• Tissue specificityUbiquitously expressed, but at very low levels in fetal and adult brain.
• PathwayProtein modification; protein glycosylation.
• Involvement in diseaseDefects in B4GALT1 are the cause of congenital disorder of glycosylation type 2D (CDG2D) [MIM:607091]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
• Sequence similaritiesBelongs to the glycosyltransferase 7 family.
• Post-translational
  modificationsThe soluble form derives from the membrane forms by proteolytic processing.
• Cellular localizationGolgi apparatus > Golgi stack membrane. Cell membrane. Cell surface. Found in trans cisternae of Golgi; Golgi apparatus > Golgi stack membrane. Found in trans cisternae of Golgi and Secreted. Soluble form found in body fluids.

Target information above from: UniProt accession P15291 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 2683 Human
  • Entrez Gene: 2683 Human
  • Omim: 137060 Human
  • SwissProt: P15291 Human
  • SwissProt: P15291 Human
  • Unigene: 272011 Human

• Alternative names
  384.Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase antibody4-galactosyltransferase 1 antibody4-GalTase 1 antibody

  b4Gal-T1 antibodyB4galt1 antibodyB4GT1_HUMAN antibodyBeta-1 antibodyBeta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase antibodyBeta4Gal-T1 antibodyGGTB2 antibodyLactose synthase A protein antibodyN-acetyllactosamine synthase antibodyNal synthase antibodyProcessed beta-1 antibodyUDP-Gal:beta-GlcNAc beta-1 antibodyUDP-galactose:beta-N-acetylglucosamine beta-1 antibody

  see all

Anti-B4GALT1 antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B4GALT1 antibody (ab121325)
  ab121325, at 1/10, staining B4GALT1 in paraffin embedded Human lateral ventricle tissue by Immunohistochemistry.