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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Proteases
Overview
Product name
Anti-BACE2 antibody
See all BACE2 products (8) ...
Description
Rabbit polyclonal to BACE2
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide: APTPGPGTPAERHADG, corresponding to amino acids 44-59 of Human BACE 2.
APTPGPGTPA ERHADG
Positive control
Human heart tissue lysate.
General notes
Beta-site APP Cleaving Enzyme
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 0.02% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Aspartic protease >> BACEs
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Proteases
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Western blot - BACE2 antibody (ab8025)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab8025 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use a concentration of 10 µg/ml
WB: Use a concentration of 0.5 - 1 µg/ml.
Target
Function
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Tissue specificity
Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Sequence similarities
Belongs to the peptidase A1 family.
Post-translational
modifications
Undergoes autoproteolytic cleavage.
Glycosylated.
Cellular localization
Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
Target information above from: UniProt accessionQ9Y5Z0
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ASP1 antibody
- Aspartyl protease 1 antibody
- Beta-site APP cleaving enzyme 2 antibody
see all
Database links
- Entrez Gene: 25825 Human
- Entrez Gene: 56175 Mouse
- Entrez Gene: 288227 Rat
- Omim: 605668 Human
- SwissProt: Q9NZL1 Human
- SwissProt: Q9NZL2 Human
- SwissProt: Q9Y5Z0 Human
- SwissProt: Q8C5E9 Mouse
see all
Anti-BACE2 antibody images:
Western blot - BACE2 antibody (ab8025)
Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with Ab8025 at 1 µg/ml.
References for Anti-BACE2 antibody (ab8025)
This product has been referenced in:
- Ahmed RRet al. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem 112:1045-53 (2010). WB; Human.Read more (PubMed: 19968762) »
See 1 publication for this product
Publishing research using ab8025? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"