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Western blot - BACE2 antibody (ab8025)
(enlarge)
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Product Name
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BACE2 antibody
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See all BACE2 antibodies (8)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to BACE2
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Immunogen
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Synthetic peptide: APTPGPGTPAERHADG, corresponding to amino acids 44-59 of Human BACE 2.
BLAST 'APTPGPGTPAERHADG' with  or 
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Reacts with
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Hu, Ms, Rat
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Tested applications
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IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: Use at a concentration of 10 µg/ml.
WB: Use at a concentration of 0.5 - 1 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
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Human heart tissue lysate.
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Cellular localization
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Plasma membrane
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Research areas
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Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Aspartic protease >> BACEs
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Proteases
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Relevance
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BACE2 (Memapsin 1) is a membrane-bound aspartic protease that is highly homologous with BACE1 (Memapsin 2). While BACE1 processes the amyloid precursor protein (APP) at a key step in generating the beta-amyloid peptide and presumably causes Alzheimer's disease (AD), BACE2 has not been demonstrated to be directly involved in APP processing, and its physiological functions remain to be determined. In vivo, BACE2 is expressed as a precursor protein containing pre-, pro-, protease, transmembrane, and cytosolic domains/peptides.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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PBS with 0.02% sodium azide Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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Batch dependent within range: 0.50 - 1.00 mg/ml
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Storage instructions
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Store at +4°C.
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Notes
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Beta-site APP Cleaving Enzyme
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BACE2 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for BACE2 antibody images, references, products related to ab8025 and other tools.
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BACE2 antibody images:
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 Western blot - BACE2 antibody (ab8025)
Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with Ab8025 at 1 µg/ml.
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References for BACE2 antibody (ab8025)
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This product has been used in:
Ahmed RR et al. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem 112:1045-53 (2010). WB; Human. PubMed: 19968762
If you publish research using ab8025 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to BACE2
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BACE2 antibody - more information
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Customer reviews (feedback) regarding BACE2 antibody |
Customer FAQs regarding BACE2 antibody |
Protocols for BACE2 antibody |
Price and availability of products related to BACE2 antibody |
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BACE2 antibody - related products:
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BACE2 antibody - other tools:
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Contact Abcam with a Technical Enquiry about BACE2 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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