Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia
Overview
Product name
Anti-BACH1/BRIP1 antibody [3G11]
See all BACH1/BRIP1 products (4) ...
Description
Mouse monoclonal [3G11] to BACH1/BRIP1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fusion protein (C-terminus of Human BACH1).
Positive control
MCF7, HeLa, 293 and U2OS cell lysates.
Properties
Form
Liquid
Storage instructions
Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
3G11
Isotype
IgG1
Applications
Show applications key
Our Abpromise guarantee covers the use of ab14383 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 3 µg/ml.Predicted molecular weight: 82 kDa.
Target
Relevance
BACH1 is a member of the DEAH helicase family that interacts with BRCA1, in vivo. BACH1 is a DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. BACH1 acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination, and is involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. The BACH1/BRCA1 complex formation contributes to a key function of BRCA1. Therefore, it is likely that BACH1 is a target of germline cancer-inducing mutations. This Bach1/Brip1 protein should not be confused with the separate Bach1 protein listed under SwissProt O14867. This other protein is a BTB and CNC homolog 1 transcription factor.
Cellular localization
Nuclear
Alternative names
- ATP dependent RNA helicase BRIP1 antibody
- BACH 1 antibody
- BRAC 1 Associated C Terminal Helicase 1 antibody
see all
Database links
- Entrez Gene: 83990 Human
- Omim: 605882 Human
- SwissProt: Q9BX63 Human
- Unigene: 532799 Human
References for Anti-BACH1/BRIP1 antibody [3G11] (ab14383)
ab14383 has not yet been referenced specifically in any publications.
Publishing research using ab14383? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"