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Anti-BACH1/BRIP1 antibody (ab7288)

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Overview

Product name

Anti-BACH1/BRIP1 antibody
See all BACH1/BRIP1 products (4) ...

Description

Rabbit polyclonal to BACH1/BRIP1

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Synthetic peptide, corresponding to amino acids 1233-1249 of Human BACH1.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> BRCT Domain Proteins
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia

  • Western blot - BACH1 antibody (ab7288)Western blot - BACH1 antibody (ab7288) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab7288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

BACH1 is a member of the DEAH helicase family that interacts with BRCA1, in vivo. BACH1 is a DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. BACH1 acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination, and is involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. The BACH1/BRCA1 complex formation contributes to a key function of BRCA1. Therefore, it is likely that BACH1 is a target of germline cancer-inducing mutations. This Bach1/Brip1 protein should not be confused with the separate Bach1 protein listed under SwissProt O14867. This other protein is a BTB and CNC homolog 1 transcription factor.

Cellular localization

Nuclear

Alternative names

  • ATP dependent RNA helicase BRIP1 antibody
  • BACH 1 antibody
  • BRAC 1 Associated C Terminal Helicase 1 antibody
  • BRAC 1 Associated C Terminal Helicase 1 antibody
  • BRCA 1 Interacting Protein 1 antibody
  • BRCA 1 Interacting Protein 1 antibody
  • BRCA1 binding helicase like protein BACH1 antibody
  • BRCA1 interacting protein C terminal helicase 1 antibody
  • BRIP 1 antibody
  • BRIP 1 antibody
  • BRIP1 antibody
  • FANCJ antibody
  • Fanconi anemia group J protein antibody
  • FLJ90232 antibody
  • MGC126521 antibody
  • MGC126523 antibody
  • OF antibody
  • Protein FACJ antibody
see all

Database links

Anti-BACH1/BRIP1 antibody images:

  Western blot - BACH1 antibody (ab7288)

Western blot - BACH1 antibody (ab7288)

All lanes : Anti-BACH1/BRIP1 antibody (ab7288) at 1/1000 dilution

Lane 1 : recombinant FLAG-tagged human BACH1
Lane 2 : IMR90 cell lysate
Lane 3 : 293 cell lysate
Lane 4 : MC7 cell lysate


Predicted band size : 140 kDa


Exposure time : 5 seconds

This was submitted as part of a review by Dr Ron Drapkin

References for Anti-BACH1/BRIP1 antibody (ab7288)

ab7288 has not yet been referenced specifically in any publications.

Publishing research using ab7288? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"