BACH1/BRIP1 antibody [pp15-IB4] (ab3641)

Product Name 

BACH1/BRIP1 antibody [pp15-IB4]

Product type 

Primary antibodies

Description 

Mouse monoclonal [pp15-IB4] to BACH1/BRIP1

Immunogen 

Partial BACH1 protein peptide.

Reacts with 
(species key)

Hu

Specificity 

The protein this antibody detects (BRIP1) is similar to BRCA1 binding helicase-like protein BACH1.

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
WB: 1/500 - 1/1000. Detects a band of approximately 130 kDa (predicted molecular weight: 137 kDa).

Is unsuitable for IF.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

HeLa whole and nuclear extracts, Raji whole extracts.

Cellular localization 

Nuclear

Research areas 

Chromatin and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Chromatin and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> Leucine Zipper
Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Synthesis >> Other
Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> BRCT Domain Proteins
Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Fanconi's Anemia

Relevance 

BACH1 is a member of the DEAH helicase family that interacts with BRCA1, in vivo. The BACH1/BRCA1 complex formation contributes to a key function of BRCA1. Therefore, it is likely that BACH1 is a target of germline cancer-inducing mutations.

This Bach1/Brip1 protein should not be confused with the separate Bach1 protein listed under SwissProt O14867. This other protein is a BTB and CNC homolog 1 transcription factor.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

pp15-IB4

Isotype 

IgG1

Purity 

Ascites

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: Ascites

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

7.400 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

See below for BACH1/BRIP1 antibody [pp15-IB4] images, references, products related to ab3641 and other tools.

BACH1/BRIP1 antibody [pp15-IB4] images:

References for BACH1/BRIP1 antibody [pp15-IB4] (ab3641)

  This product has been used in:

Cantor SB et al. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 105:149-60 (2001). PubMed: 11301010
If you publish research using ab3641 please let us know so that we can cite the reference on this datasheet.

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