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Anti-BAFF antibody (ab8396)

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Overview

Product name

Anti-BAFF antibody
See all BAFF products (12) ...

Description

Rabbit polyclonal to BAFF

Tested applications

ICC/IF, WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide, corresponding to amino acids 254-269 of Human BAFF.

Positive control

HL60 cell lysate

General notes

BAFF is also known as B cell Activating Factor

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

PBS with 0.02% sodium azide

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Polyclonal

Isotype

IgG

Light chain type

unknown

  • Western blot - BAFF antibody (ab8396)Western blot - BAFF antibody (ab8396) image (enlarge)

  • Immunocytochemistry/ Immunofluorescence - BAFF antibody (ab8396)Immunocytochemistry/ Immunofluorescence - BAFF antibody (ab8396) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab8396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

Tissue specificity

Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.

Sequence similarities

Belongs to the tumor necrosis factor family.

Post-translational
modifications

The soluble form derives from the membrane form by proteolytic processing.
N-glycosylated.

Cellular localization

Secreted and Cell membrane.

Target information above from: UniProt accessionQ9Y275 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • soluble form antibody
  • ApoL related ligand TALL 1 antibody
  • B cell Activating Factor antibody
  • B cell Activating Factor antibody
  • B lymphocyte stimulator antibody
  • B-cell-activating factor antibody
  • BAFF antibody
  • BLYS antibody
  • CD 257 antibody
  • CD257 antibody
  • CD257 antigen antibody
  • delta BAFF antibody
  • Dendritic cell derived TNF like molecule antibody
  • Dendritic cell-derived TNF-like molecule antibody
  • DTL antibody
  • DTL precursor antibody
  • PRO738 antibody
  • TALL 1 antibody
  • TALL-1 antibody
  • TALL1 antibody
  • THANK antibody
  • TN13B_HUMAN antibody
  • TNF and APOL related leukocyte expressed ligand 1 antibody
  • TNF homolog that activates apoptosis antibody
  • TNF homolog that activates apoptosis NKFB and JNK. antibody
  • TNF- and APOL-related leukocyte expressed ligand 1 antibody
  • TNFSF13B antibody
  • TNFSF20 antibody
  • Tumor necrosis factor ligand superfamily member 13B antibody
  • Tumor necrosis factor ligand superfamily member 20 antibody
  • Tumor necrosis factor like protein ZTNF4 antibody
  • Tumor necrosis factor superfamily member 13B antibody
  • UNQ401 antibody
  • ZTNF4 antibody
see all

Anti-BAFF antibody images:

  Western blot - BAFF antibody (ab8396)

Western blot - BAFF antibody (ab8396)

All lanes : Anti-BAFF antibody (ab8396) at 1 µg/ml

Lane 1 : Human HL60 cell lysate
Lane 2 : Murine spleen tissue lysate


Observed band size : 34 kDa (why is the actual band size different from the predicted?)

  Immunocytochemistry/ Immunofluorescence - BAFF antibody (ab8396)

Immunocytochemistry/ Immunofluorescence - BAFF antibody (ab8396)

ab8396 at 1µg/ml staining BAFF in HL60 cells by ICC/IF

References for Anti-BAFF antibody (ab8396)

ab8396 has not yet been referenced specifically in any publications.

Publishing research using ab8396? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"