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Products:Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Overview
Product name
Anti-BANP antibody
See all BANP products (4) ...
Description
Rabbit polyclonal to BANP
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide corresponding to a region within C terminal amino acids 425-469 (GQLLEATRIP CLLAPSVFKA SSGQVLQGAQ LIAVASSDPA AAGVDG) of human BANP (SwissProt Q96GJ7).
GQLLEATRIP CLLAPSVFKA SSGQVLQGAQ LIAVASSDPA AAGVDG
Positive control
Human breast tumor; mouse squamous cell carcinoma.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
The antibody was affinity purified using an epitope specific to BANP immobilized on solid support.
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab84376 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 2 Images
IHC-P
Application notes
IHC-P: 1/100 - 1/500.
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest.
Tissue specificity
Down-regulated in breast cancer cell lines.
Sequence similarities
Belongs to the BANP/SMAR1 family.
Contains 1 BEN domain.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ8N9N5
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AAH09424 antibody
- Banp antibody
- BANP_HUMAN antibody
see all
Database links
- Entrez Gene: 54971 Human
- Entrez Gene: 53325 Mouse
- Omim: 611564 Human
- SwissProt: Q8N9N5 Human
- SwissProt: Q8VBU8 Mouse
- Unigene: 461705 Human
- Unigene: 287163 Mouse
Anti-BANP antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BANP antibody (ab84376)
ab84376, at a 1/250 dilution, staining BANP in formalin fixed, paraffin embedded human breast tumor by Immunohistochemistry.
Detection: by DAB staining
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BANP antibody (ab84376)
ab84376, at a 1/250 dilution, staining BANP in formalin fixed, paraffin embedded mouse squamous cell carcinoma by Immunohistochemistry.
Detection: by DAB staining
References for Anti-BANP antibody (ab84376)
ab84376 has not yet been referenced specifically in any publications.
Publishing research using ab84376? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"