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Products:Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Overview
Product name
BANP peptide
Protein description
Synthetic peptide derived from residues 200 - 250 of Human BANP.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration
Concentration information loading...
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab40428 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking
Application notes
BL: Use at an assay dependent dilution. (Suitable for use in blocking for immunoprecipitation, immunocytochemistry, Western blotting and dot blots).
This peptide can be used with studies using ab23762.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest.
Tissue specificity
Down-regulated in breast cancer cell lines.
Sequence similarities
Belongs to the BANP/SMAR1 family.
Contains 1 BEN domain.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ8N9N5
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for BANP peptide (ab40428)
ab40428 has not yet been referenced specifically in any publications.
Publishing research using ab40428? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"