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Product Name
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BAP1 antibody [3c11]
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See all BAP1 antibodies (2)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [3c11] to BAP1
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Immunogen
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Recombinant full length protein (Human).
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Reacts with
(species key)
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Hu
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Epitope
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Recognizes an epitope within the region of amino acids 337-440 of the human BAP1 molecule.
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Tested applications
(see key)
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ICC, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ICC: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
WB: 1/2000. Detects a band of approximately 81 kDa (predicted molecular weight: 81 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Whole cell extract of human melanoma cell line.
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Cellular localization
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Nuclear
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Research areas
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Cancer >> Cell cycle >> Cell cycle inhibitors >> Other
Chromatin and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Other
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Other
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Relevance
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BRCA1 Associated Protein 1 (BAP1), a 81 kD protein encoded by the BAP1 gene that is proposed to be a tumor suppressor gene, functions in the BRCA1 growth control pathway, by enhancing the BRCA1-mediated inhibition of breast cancer cell growth. BAP1 is a nuclear-localized, ubiquitin C-terminal hydrolase, that binds to the wild-type RING finger domain of BRCA1. It does not bind to germline mutants of the BRCA1-RING finger found in breast cancer kindreds. Murine BAP1 and BRCA1 are temporally and spatially co-expressed during murine breast development and remodeling, and show overlapping patterns of subnuclear distribution. BAP1 resides on human chromosome 3p21.3, and rearrangements, deletions and missense mutations of BAP1 have been found in lung carcinoma cell lines and in primary breast tumor samples. Antibodies reacting specifically with BAP1 are useful tools in the study of the detailed mechanisms of BRCA1 growth control pathways, and its essential roles during developmental and pathological processes.
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BAP1 antibody [3c11] (ab10531) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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3c11
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Isotype
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IgG1
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Purity
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Ascites
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Storage buffer
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Preservative: 15mM Sodium Azide
Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BAP1 antibody [3c11] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to BAP1
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BAP1 antibody [3c11] - more information
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Customer reviews (feedback) regarding BAP1 antibody [3c11] |
Customer FAQs regarding BAP1 antibody [3c11] |
Protocols for BAP1 antibody [3c11] |
Price and availability of products related to BAP1 antibody [3c11] |
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BAP1 antibody [3c11] - related products:
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BAP1 antibody [3c11] - other tools:
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Contact Abcam with a Technical Enquiry about BAP1 antibody [3c11] |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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