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- BCAR1 antibody [SPM302], prediluted (ab17745)
![- BCAR1 antibody [SPM302], prediluted (ab17745)](/ps/datasheet/images/ab17745_1.jpg)
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Product Name
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BCAR1 antibody [SPM302], prediluted
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See all BCAR1 antibodies (15)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [SPM302] to BCAR1, prediluted
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Immunogen
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Recombinant full length protein (Human).
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Reacts with
(species key)
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Hu, Rat
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Epitope
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Not determined
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Tested applications
(see key)
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IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/1. Requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temp for 20 min.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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MCF-7 cells, HUVEC cells. Tonsil or breast carcinoma.
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Cellular localization
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Focal adhesions. Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.
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Research areas
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Cancer >> Signal transduction >> Other
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
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Relevance
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BCAR1 has a unique structure that contains a Src homology (SH)3 domain followed by multiple YXXP motifs and a proline rich region. It is a docking protein which plays a central coordinating role for tyrosine kinase based signaling related to cell adhesion. It is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement, bacterial infection, cardiovascular development, actin filament assembly and Src induced cell transformation. Overexpression confers antiestrogen resistance on breast cancer cells.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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SPM302
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: Sodium Azide
Constituents: BSA, 10mM PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Prediluted
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BCAR1 antibody [SPM302], prediluted is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for BCAR1 antibody [SPM302], prediluted images, references, products related to ab17745 and other tools.
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BCAR1 antibody [SPM302], prediluted images:
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 - BCAR1 antibody [SPM302], prediluted (ab17745)
Human breast cancer stained with ab17745.
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Search PubMed (MEDLINE) for references to BCAR1
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BCAR1 antibody [SPM302], prediluted - more information
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Customer reviews (feedback) regarding BCAR1 antibody [SPM302], prediluted |
Customer FAQs regarding BCAR1 antibody [SPM302], prediluted |
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BCAR1 antibody [SPM302], prediluted - related products:
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BCAR1 antibody [SPM302], prediluted - other tools:
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Contact Abcam with a Technical Enquiry about BCAR1 antibody [SPM302], prediluted |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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![- BCAR1 antibody [SPM302], prediluted (ab17745)](/index.html?datasheet=17745#ab17745_1.jpg)
