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Anti-BCL2L1 antibody [7B2.5] (Biotin) (ab25062)

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Overview

Product name

Anti-BCL2L1 antibody [7B2.5] (Biotin)
See all BCL2L1 products (30) ...

Description

Mouse monoclonal [7B2.5] to BCL2L1 (Biotin)

Conjugation

Biotin

Tested applications

IP, Flow Cyt, WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length Bcl xL protein (Human).

Properties

Form

Liquid

Storage instructions

Store at +4°C in the dark.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

7B2.5

Isotype

IgG3

Applications

Show applications key

Our Abpromise guarantee covers the use of ab25062 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
Isoform Bcl-X(S) promotes apoptosis.

Tissue specificity

Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Sequence similarities

Belongs to the Bcl-2 family.

Domain

The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.

Post-translational
modifications

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.

Cellular localization

Mitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.

Target information above from: UniProt accessionQ07817 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Apoptosis regulator Bcl X antibody
  • Apoptosis regulator Bcl-X antibody
  • Apoptosis regulator BclX antibody
  • B cell lymphoma 2 like antibody
  • B2CL1_HUMAN antibody
  • Bcl 2 like 1 protein antibody
  • Bcl X antibody
  • Bcl xL antibody
  • BCL XL/S antibody
  • Bcl xS antibody
  • Bcl-2-like protein 1 antibody
  • Bcl2 Like 1 antibody
  • Bcl2 related gene antibody
  • Bcl2-L-1 antibody
  • BCL2L antibody
  • Bcl2l1 antibody
  • BCLX antibody
  • BclXL antibody
  • BclXs antibody
  • DKFZp781P2092 antibody
see all

References for Anti-BCL2L1 antibody [7B2.5] (Biotin) (ab25062)

ab25062 has not yet been referenced specifically in any publications.

Publishing research using ab25062? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"